TY - JOUR
T1 - Low and high-frequency somatosensory evoked potentials recorded from the human pedunculopontine nucleus
AU - Insola, Angelo
AU - Padua, Luca
AU - Mazzone, Paolo
AU - Scarnati, Eugenio
AU - Valeriani, Massimiliano
PY - 2014
Y1 - 2014
N2 - Objective: To investigate the generators of the somatosensory evoked potential (SEP) components recorded from the Pedunculopontine Tegmental nucleus (PPTg). Methods: Twenty-two patients, suffering from Parkinson's disease (PD), underwent electrode implantation in the PPTg area for deep brain stimulation (DBS). SEPs were recorded from the DBS electrode contacts to median nerve stimulation. Results: SEPs recorded from the PPTg electrode contacts could be classified in 3 types, according to their waveforms. (1) The biphasic potential showed a positive peak (P16) whose latency (16.05 ± 0.61 ms) shifted of 0.18 ± 0.07 ms from the lower to the upper contact of the electrode. (2) The triphasic potential showed an initial positive peak (P15) whose latency (15.4 ± 0.2 ms) did not change across the DBS electrode contacts. (3) In the last SEP configuration (mixed biphasic and triphasic waveform), the positive peak was bifid including both the P15 and P16 potentials. Conclusion: While the P16 potential is probably generated by the somatosensory volley travelling along the medial lemniscus, the P15 response represents a far-field potential probably generated at the cuneate nucleus level. Significance: Our results show the physiological meaning of the somatosensory responses recorded from the PPTg nucleus area. © 2014 International Federation of Clinical Neurophysiology.
AB - Objective: To investigate the generators of the somatosensory evoked potential (SEP) components recorded from the Pedunculopontine Tegmental nucleus (PPTg). Methods: Twenty-two patients, suffering from Parkinson's disease (PD), underwent electrode implantation in the PPTg area for deep brain stimulation (DBS). SEPs were recorded from the DBS electrode contacts to median nerve stimulation. Results: SEPs recorded from the PPTg electrode contacts could be classified in 3 types, according to their waveforms. (1) The biphasic potential showed a positive peak (P16) whose latency (16.05 ± 0.61 ms) shifted of 0.18 ± 0.07 ms from the lower to the upper contact of the electrode. (2) The triphasic potential showed an initial positive peak (P15) whose latency (15.4 ± 0.2 ms) did not change across the DBS electrode contacts. (3) In the last SEP configuration (mixed biphasic and triphasic waveform), the positive peak was bifid including both the P15 and P16 potentials. Conclusion: While the P16 potential is probably generated by the somatosensory volley travelling along the medial lemniscus, the P15 response represents a far-field potential probably generated at the cuneate nucleus level. Significance: Our results show the physiological meaning of the somatosensory responses recorded from the PPTg nucleus area. © 2014 International Federation of Clinical Neurophysiology.
KW - Cuneate nucleus
KW - Deep brain stimulation
KW - High frequency oscillations
KW - Medial lemniscus
KW - PPTg
KW - Somatosensory evoked potential
KW - Cuneate nucleus
KW - Deep brain stimulation
KW - High frequency oscillations
KW - Medial lemniscus
KW - PPTg
KW - Somatosensory evoked potential
UR - http://hdl.handle.net/10807/54112
U2 - 10.1016/j.clinph.2013.12.112
DO - 10.1016/j.clinph.2013.12.112
M3 - Article
SN - 1872-8952
SP - N/A-N/A
JO - Clinical Neurophysiology
JF - Clinical Neurophysiology
ER -