Loss of CDKN2A and p14ARF expression occurs frequently in human nonmelanoma skin cancers

A Pacifico; Lh Goldberg; Ketty Peris; S Chimenti; G Leone; Hn Ananthaswamy

doi:10.1111/j.1365-2133.2007.08360.x

Loss of CDKN2A and p14ARF expression occurs frequently in human nonmelanoma skin cancers

A Pacifico, Lh Goldberg, Ketty Peris, S Chimenti, G Leone, Hn Ananthaswamy

Risultato della ricerca: Contributo in rivista › Articolo in rivista

36 Citazioni (Scopus)

Abstract

The CDKN2A locus on human chromosome 9p21 encodes two proteins named p16INK4a and p14ARF, known to function as tumour suppressors via the retinoblastoma (Rb) or the p53 pathway. The p53 tumour suppressor gene is the most commonly mutated gene in human and mouse cancers. Disruption of the p53 and Rb pathways is a fundamental trend of most human cancer cells. Recent studies have shown that the CDKN2A gene plays an active role in the p53 and Rb tumour suppressor pathways. Genetic abnormalities in CDKN2A have been well documented in human melanoma, but their involvement in nonmelanoma skin cancer (NMSC) is less clear.

Lingua originale	English
pagine (da-a)	291-297
Numero di pagine	7
Rivista	British Journal of Dermatology
Volume	158
DOI	https://doi.org/10.1111/j.1365-2133.2007.08360.x
Stato di pubblicazione	Pubblicato - 2008

Keywords

Adult
Aged
Aged, 80 and over
Carcinoma, Basal Cell
Carcinoma, Squamous Cell
Female
Genes, p16
Humans
Keratosis
Male
Middle Aged
Mutation
Skin Neoplasms
Tumor Suppressor Protein p14ARF

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title = "Loss of CDKN2A and p14ARF expression occurs frequently in human nonmelanoma skin cancers",

abstract = "The CDKN2A locus on human chromosome 9p21 encodes two proteins named p16INK4a and p14ARF, known to function as tumour suppressors via the retinoblastoma (Rb) or the p53 pathway. The p53 tumour suppressor gene is the most commonly mutated gene in human and mouse cancers. Disruption of the p53 and Rb pathways is a fundamental trend of most human cancer cells. Recent studies have shown that the CDKN2A gene plays an active role in the p53 and Rb tumour suppressor pathways. Genetic abnormalities in CDKN2A have been well documented in human melanoma, but their involvement in nonmelanoma skin cancer (NMSC) is less clear.",

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author = "A Pacifico and Lh Goldberg and Ketty Peris and S Chimenti and G Leone and Hn Ananthaswamy",

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doi = "10.1111/j.1365-2133.2007.08360.x",

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T1 - Loss of CDKN2A and p14ARF expression occurs frequently in human nonmelanoma skin cancers

AU - Pacifico, A

AU - Goldberg, Lh

AU - Peris, Ketty

AU - Chimenti, S

AU - Leone, G

AU - Ananthaswamy, Hn

PY - 2008

Y1 - 2008

N2 - The CDKN2A locus on human chromosome 9p21 encodes two proteins named p16INK4a and p14ARF, known to function as tumour suppressors via the retinoblastoma (Rb) or the p53 pathway. The p53 tumour suppressor gene is the most commonly mutated gene in human and mouse cancers. Disruption of the p53 and Rb pathways is a fundamental trend of most human cancer cells. Recent studies have shown that the CDKN2A gene plays an active role in the p53 and Rb tumour suppressor pathways. Genetic abnormalities in CDKN2A have been well documented in human melanoma, but their involvement in nonmelanoma skin cancer (NMSC) is less clear.

AB - The CDKN2A locus on human chromosome 9p21 encodes two proteins named p16INK4a and p14ARF, known to function as tumour suppressors via the retinoblastoma (Rb) or the p53 pathway. The p53 tumour suppressor gene is the most commonly mutated gene in human and mouse cancers. Disruption of the p53 and Rb pathways is a fundamental trend of most human cancer cells. Recent studies have shown that the CDKN2A gene plays an active role in the p53 and Rb tumour suppressor pathways. Genetic abnormalities in CDKN2A have been well documented in human melanoma, but their involvement in nonmelanoma skin cancer (NMSC) is less clear.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Carcinoma, Basal Cell

KW - Carcinoma, Squamous Cell

KW - Female

KW - Genes, p16

KW - Humans

KW - Keratosis

KW - Male

KW - Middle Aged

KW - Mutation

KW - Skin Neoplasms

KW - Tumor Suppressor Protein p14ARF

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Carcinoma, Basal Cell

KW - Carcinoma, Squamous Cell

KW - Female

KW - Genes, p16

KW - Humans

KW - Keratosis

KW - Male

KW - Middle Aged

KW - Mutation

KW - Skin Neoplasms

KW - Tumor Suppressor Protein p14ARF

UR - http://hdl.handle.net/10807/57532

U2 - 10.1111/j.1365-2133.2007.08360.x

DO - 10.1111/j.1365-2133.2007.08360.x

M3 - Article

SN - 1365-2133

VL - 158

SP - 291

EP - 297

JO - British Journal of Dermatology

JF - British Journal of Dermatology

ER -

Loss of CDKN2A and p14ARF expression occurs frequently in human nonmelanoma skin cancers

Abstract

Keywords

OSS delle Nazioni Unite

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