Longitudinal reproducibility of default-mode network connectivity in healthy elderly participants: A multicentric resting-state fMRI study

Camillo Marra, Paolo Maria Rossini, Jorge Jovicich, Ludovico Minati, Moira Marizzoni, Rocco Marchitelli, Roser Sala-Llonch, David Bartrés-Faz, Jennifer Arnold, Jens Benninghoff, Ute Fiedler, Luca Roccatagliata, Agnese Picco, Flavio Nobili, Oliver Blin, Stephanie Bombois, Renaud Lopes, Régis Bordet, Julien Sein, Jean-Philippe RanjevaMira Didic, Hélène Gros-Dagnac, Pierre Payoux, Giada Zoccatelli, Franco Alessandrini, Alberto Beltramello, Núria Bargalló, Antonio Ferretti, Massimo Caulo, Marco Aiello, Carlo Cavaliere, Andrea Soricelli, Lucilla Parnetti, Roberto Tarducci, Piero Floridi, Magda Tsolaki, Manos Constantinidis, Antonios Drevelegas, Peter Schönknecht, Tilman Hensch, Karl-Titus Hoffmann, Joost P. Kuijer, Pieter Jelle Visser, Frederik Barkhof, Giovanni B. Frisoni

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

50 Citazioni (Scopus)

Abstract

To date, limited data are available regarding the inter-site consistency of test-retest reproducibility of functional connectivity measurements, in particular with regard to integrity of the Default Mode Network (DMN) in elderly participants. We implemented a harmonized resting-state fMRI protocol on 13 clinical scanners at 3.0T using vendor-provided sequences. Each site scanned a group of 5 healthy elderly participants twice, at least a week apart. We evaluated inter-site differences and test-retest reproducibility of both temporal signal-to-noise ratio (tSNR) and functional connectivity measurements derived from: i) seed-based analysis (SBA) with seed in the posterior cingulate cortex (PCC), ii) group independent component analysis (ICA) separately for each site (site ICA), and iii) consortium ICA, with group ICA across the whole consortium. Despite protocol harmonization, significant and quantitatively important inter-site differences remained in the tSNR of resting-state fMRI data; these were plausibly driven by hardware and pulse sequence differences across scanners which could not be harmonized. Nevertheless, the tSNR test-retest reproducibility in the consortium was high (ICC=0.81). The DMN was consistently extracted across all sites and analysis methods. While significant inter-site differences in connectivity scores were found, there were no differences in the associated test-retest error. Overall, ICA measurements were more reliable than PCC-SBA, with site ICA showing higher reproducibility than consortium ICA. Across the DMN nodes, the PCC yielded the most reliable measurements (≈4% test-retest error, ICC=0.85), the medial frontal cortex the least reliable (≈12%, ICC=0.82) and the lateral parietal cortices were in between (site ICA). Altogether these findings support usage of harmonized multisite studies of resting-state functional connectivity to characterize longitudinal effects in studies that assess disease progression and treatment response.
Lingua originaleEnglish
pagine (da-a)442-454
Numero di pagine13
RivistaNeuroImage
Volume124
DOI
Stato di pubblicazionePubblicato - 2016

Keywords

  • Default Mode Network
  • Functional connectivity
  • Multi-center
  • Multi-site MRI
  • Reproducibility

Fingerprint Entra nei temi di ricerca di 'Longitudinal reproducibility of default-mode network connectivity in healthy elderly participants: A multicentric resting-state fMRI study'. Insieme formano una fingerprint unica.

Cita questo