Longitudinal changes in functional brain connectivity predicts conversion to Alzheimer's disease

Laura Serra, Mara Cercignani, Chiara Mastropasqua, Mario Torso, Barbara Spanò, Elena Makovac, Vanda Viola, Giovanni Giulietti, Camillo Marra, Carlo Caltagirone, Marco Bozzali

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

35 Citazioni (Scopus)


This longitudinal study investigates the modifications in structure and function occurring to typical Alzheimer's disease (AD) brains over a 2-year follow-up, from pre-dementia stages of disease, with the aim of identifying biomarkers of prognostic value. Thirty-one patients with amnestic mild cognitive impairment were recruited and followed-up with clinical, neuropsychological, and MRI assessments. Patients were retrospectively classified as AD Converters or Non-Converters, and the data compared between groups. Cross-sectional MRI data at baseline, assessing volume and functional connectivity abnormalities, confirmed previous findings, showing a more severe pattern of regional grey matter atrophy and default-mode network disconnection in Converters than in Non-Converters. Longitudinally, Converters showed more grey matter atrophy in the frontotemporal areas, accompanied by increased connectivity in the precuneus. Discriminant analysis revealed that functional connectivity of the precuneus within the default mode network at baseline is the parameter able to correctly classify patients in Converters and Non-Converters with high sensitivity, specificity, and accuracy.
Lingua originaleEnglish
pagine (da-a)377-389
Numero di pagine13
RivistaJournal of Alzheimer's Disease
Stato di pubblicazionePubblicato - 2016


  • Aged
  • Alzheimer Disease
  • Alzheimer's disease
  • Atrophy
  • Brain
  • Brain Mapping
  • Clinical Psychology
  • Cognitive Dysfunction
  • Cross-Sectional Studies
  • Discriminant Analysis
  • Disease Progression
  • Female
  • Follow-Up Studies
  • Geriatrics and Gerontology
  • Gray Matter
  • Humans
  • Image Processing, Computer-Assisted
  • Longitudinal Studies
  • Magnetic Resonance Imaging
  • Male
  • Neural Pathways
  • Neuropsychological Tests
  • Prognosis
  • Psychiatry and Mental Health
  • Rest
  • functional disconnection
  • grey matter atrophy
  • longitudinal study
  • mild cognitive impairment


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