Long-term treatment with infliximab in inflammatory bowel disease: Safety and tolerability issues

Renato Caviglia, Ivo Boskoski, Michele Cicala, Carlo Maria Cicala

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

Crohn's disease and ulcerative colitis represent the most common forms of inflammatory bowel disease (IBD), clinical conditions affecting the small and/or large bowel. It is well known that IBD is an immune-mediated condition and that TNF-α plays a pivotal role in the pathogenesis of the disease. TNF-α has been scrupulously studied as a target for therapeutic intervention in this setting. A number of biologic compounds have been developed, including the European Medicine Agency (EMEA)-approved agents, infliximab and adalimumab. Although their efficacy in induction and maintenance of remission has been established by several clinical trials, many issues regarding safety remain to be elucidated. In fact, anti-TNF treatment may be associated with a number of rare, but serious, adverse events, including infusion reactions, infections, lymphomas and other malignancies. A black-box warning has to be taken into consideration when looking at potential serious infections such as tuberculosis. Active infections, demyelinating disorders and severe heart failure are contraindications for anti-TNF treatment. This review focuses on drug toxicity and adverse events related to infliximab treatment in IBD. © 2008 Informa UK Ltd.
Lingua originaleEnglish
pagine (da-a)617-632
Numero di pagine16
RivistaExpert Opinion on Drug Safety
Volume7
DOI
Stato di pubblicazionePubblicato - 2008

Keywords

  • Crohn's disease
  • Infections
  • Inflammatory bowel disease
  • Infliximab
  • Malignancy
  • Safety
  • Ulcerative colitis

Fingerprint

Entra nei temi di ricerca di 'Long-term treatment with infliximab in inflammatory bowel disease: Safety and tolerability issues'. Insieme formano una fingerprint unica.

Cita questo