Long-term shaping of corticostriatal synaptic activity by acute fasting

Federica Campanelli, Paolo Calabresi, Daniela Laricchiuta, Valeria Calabrese, Barbara Picconi, Laura Petrosini, Veronica Ghiglieri

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

Food restriction is a robust nongenic, nonsurgical and nonpharmacologic intervention known to improve health and extend lifespan in various species. Food is considered the most essential and frequently consumed natural reward, and current observations have demonstrated homeostatic responses and neuroadaptations to sustained intermittent or chronic deprivation. Results obtained to date indicate that food deprivation affects glutamatergic synapses, favoring the insertion of GluA2-lacking α-Ammino-3-idrossi-5-Metil-4-idrossazol-Propionic Acid receptors (AMPARs) in postsynaptic membranes. Despite an increasing number of studies pointing towards specific changes in response to dietary restrictions in brain regions, such as the nucleus accumbens and hippocampus, none have investigated the long-term effects of such practice in the dorsal striatum. This basal ganglia nucleus is involved in habit formation and in eating behavior, especially that based on dopaminergic control of motivation for food in both humans and animals. Here, we explored whether we could retrieve long-term signs of changes in AMPARs subunit composition in dorsal striatal neurons of mice acutely deprived for 12 h/day for two consecutive days by analyzing glutamatergic neurotransmission and the principal forms of dopamine and glutamate-dependent synaptic plasticity. Overall, our data show that a moderate food deprivation in experimental animals is a salient event mirrored by a series of neuroadaptations and suggest that dietary restriction may be determinant in shaping striatal synaptic plasticity in the physiological state.
Lingua originaleEnglish
pagine (da-a)1-13
Numero di pagine13
RivistaInternational Journal of Molecular Sciences
Volume22
DOI
Stato di pubblicazionePubblicato - 2021

Keywords

  • Calcium-permeable AMPA
  • Dietary restriction
  • Naphthyl-acetyl spermine
  • Food deprivation
  • GluA1
  • Dorsolateral striatum

Fingerprint Entra nei temi di ricerca di 'Long-term shaping of corticostriatal synaptic activity by acute fasting'. Insieme formano una fingerprint unica.

Cita questo