Long-term results of a multicenter study on subthalamic and pallidal stimulation in Parkinson's disease

Elena Moro, Andres M. Lozano, Pierre Pollak, Yves Agid, Stig Rehncrona, Jens Volkmann, Jaime Kulisevsky, Jose A. Obeso, Alberto Albanese, Marwan I. Hariz, Niall P. Quinn, Jans D. Speelman, Alim L. Benabid, Valerie Fraix, Alexandre Mendes, Marie-Laure Welter, Jean-Luc Houeto, Philippe Cornu, Didier Dormont, Annalena L. TornqvistRon Ekberg, Alfons Schnitzler, Lars Timmermann, Lars Wojtecki, Andres Gironell, Maria C. Rodriguez-Oroz, Jorge Guridi, Anna Rita Bentivoglio, Maria Fiorella Contarino, Luigi Romito, Luigi Michele Antonio Romito, Massimo Scerrati, Marc Janssens, Anthony E. Lang

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

317 Citazioni (Scopus)


We report the 5 to 6 year follow-up of a multicenter study of bilateral subthalamic nucleus (STN) and globus pallidus internus (GPi) deep brain stimulation (DBS) in advanced Parkinson's disease (PD) patients. Thirty-five STN patients and 16 GPi patients were assessed at 5 to 6 years after DBS surgery. Primary outcome measure was the stimulation effect on the motor Unified Parkinson's Disease Rating Scale (UPDRS) assessed with a prospective cross-over double-blind assessment without medications (stimulation was randomly switched on or off). Secondary outcomes were motor UPDRS changes with unblinded assessments in off- and on-medication states with and without stimulation, activities of daily living (ADL), anti-PD medications, and dyskinesias. In double-blind assessment, both STN and GPi DBS were significantly effective in improving the motor UPDRS scores (STN, P < 0.0001, 45.4%; GPi, P = 0.008, 20.0%) compared with off-stimulation, regardless of the sequence of stimulation. In open assessment, both STN- and GPi-DBS significantly improved the off-medication motor UPDRS when compared with before surgery (STN, P < 0.001, 50.5%; GPi, P = 0.002, 35.6%). Dyskinesias and ADL were significantly improved in both groups. Anti-PD medications were significantly reduced only in the STN group. Adverse events were more frequent in the STN group. These results confirm the long-term efficacy of STN and GPi DBS in advanced PD. Although the surgical targets were not randomized, there was a trend to a better outcome of motor signs in the STN-DBS patients and fewer adverse events in the GPi-DBS group.
Lingua originaleEnglish
pagine (da-a)578-586
Numero di pagine9
RivistaMovement Disorders
Stato di pubblicazionePubblicato - 2010


  • Aged
  • Cross-Over Studies
  • Deep Brain Stimulation
  • Double-Blind Method
  • Female
  • Follow-Up Studies
  • Globus Pallidus
  • Humans
  • Male
  • Middle Aged
  • Parkinson Disease
  • Severity of Illness Index
  • Subthalamus
  • Time Factors
  • Treatment Outcome


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