Long-term results of a multicenter study on subthalamic and pallidal stimulation in Parkinson's disease

Alberto Albanese, Anna Rita Bentivoglio, Maria Fiorella Contarino, Luigi Michele Antonio Romito, Elena Moro, Andres M. Lozano, Pierre Pollak, Yves Agid, Stig Rehncrona, Jens Volkmann, Jaime Kulisevsky, Jose A. Obeso, Marwan I. Hariz, Niall P. Quinn, Jans D. Speelman, Alim L. Benabid, Valerie Fraix, Alexandre Mendes, Marie-Laure Welter, Jean-Luc HouetoPhilippe Cornu, Didier Dormont, Annalena L. Tornqvist, Ron Ekberg, Alfons Schnitzler, Lars Timmermann, Lars Wojtecki, Andres Gironell, Maria C. Rodriguez-Oroz, Jorge Guridi, Marc Janssens, Anthony E. Lang

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316 Citazioni (Scopus)

Abstract

We report the 5 to 6 year follow-up of a multicenter study of bilateral subthalamic nucleus (STN) and globus pallidus internus (GPi) deep brain stimulation (DBS) in advanced Parkinson's disease (PD) patients. Thirty-five STN patients and 16 GPi patients were assessed at 5 to 6 years after DBS surgery. Primary outcome measure was the stimulation effect on the motor Unified Parkinson's Disease Rating Scale (UPDRS) assessed with a prospective cross-over double-blind assessment without medications (stimulation was randomly switched on or off). Secondary outcomes were motor UPDRS changes with unblinded assessments in off- and on-medication states with and without stimulation, activities of daily living (ADL), anti-PD medications, and dyskinesias. In double-blind assessment, both STN and GPi DBS were significantly effective in improving the motor UPDRS scores (STN, P < 0.0001, 45.4%; GPi, P = 0.008, 20.0%) compared with off-stimulation, regardless of the sequence of stimulation. In open assessment, both STN- and GPi-DBS significantly improved the off-medication motor UPDRS when compared with before surgery (STN, P < 0.001, 50.5%; GPi, P = 0.002, 35.6%). Dyskinesias and ADL were significantly improved in both groups. Anti-PD medications were significantly reduced only in the STN group. Adverse events were more frequent in the STN group. These results confirm the long-term efficacy of STN and GPi DBS in advanced PD. Although the surgical targets were not randomized, there was a trend to a better outcome of motor signs in the STN-DBS patients and fewer adverse events in the GPi-DBS group.
Lingua originaleEnglish
pagine (da-a)578-586
Numero di pagine9
RivistaMovement Disorders
Volume25
DOI
Stato di pubblicazionePubblicato - 2010

Keywords

  • Aged
  • Cross-Over Studies
  • Deep Brain Stimulation
  • Double-Blind Method
  • Female
  • Follow-Up Studies
  • Globus Pallidus
  • Humans
  • Male
  • Middle Aged
  • Parkinson Disease
  • Severity of Illness Index
  • Subthalamus
  • Time Factors
  • Treatment Outcome

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