Long-term outcomes in ypT0 rectal cancers: An international multi-centric investigation on behalf of Italian Society of Surgical Oncology Young Board (YSICO)

Alberto Biondi, Domenico D'Ugo, Roberto Persiani, Laura Lorenzon, D. Parini, D. Rega, A. Mellano, V. Vigorita, R. Jaminez-Rosellon, M. Scheiterle, I. Giannini, G. Gallo, G. Marino, L. Turati, P. Marsanic, L. De Franco, L. Marano, P. Delrio, G. Balducci, G. MontesiA. Muratore, A. R. Poblador, M. Frasson, F. Roviello, L. Vincenti, M. Trompetto, G. La Torre, G. Sgroi, A. Patriti, M. Simone, R. De Luca

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

6 Citazioni (Scopus)


Aim To investigate the outcome and pattern of survivals of rectal cancer patients presenting a complete or nearly complete tumor response after neo-adjuvant treatment. Methods Young surgeons <40 years old affiliated to the Italian Society of Surgical Oncology (YSICO) from 13 referral centers for colorectal cancer treatment, were invited to participate a retrospective study. Records from patients treated from 2005 to 2015 with a pathological diagnosis of ypT0/ypTis were retrieved and pooled in a common data-base for statistical purposes. All clinical and pathological variables were reviewed. Univariate and multivariate analyses were conducted with the end-point of survivals. Results Two hundreds and sixty-one patients were analyzed including 237 ypT0 and 24 ypTis. Nodal positive patients were 8.7%. More than sixty-six percent of the patients did not perform adjuvant chemotherapy, with a statistical difference comparing N0 versus N+ patients (66.8% vs 40.9%, p 0.02). Mean follow-up was of 47.6 months. Twenty-two relapses were observed, 91.6% at a distant site. The mean time to recurrence was of 35.3 months. On univariate analysis, the use of adjuvant chemotherapy correlated with better OS exclusively in ypT0N + patients and not in ypT0N0. Univariate and multivariate analyses documented nodal positivity as the only prognostic factor correlated with a worse OS. Conclusion Recurrences were mostly diagnosed at a distant site and within the third year of follow-up. Nodal positivity was the only variable independently correlated with a worse OS. Univariate analysis documented a benefit for the use of adjuvant chemotherapy treatment exclusively in ypT0N + rectal cancers.
Lingua originaleEnglish
pagine (da-a)1472-1480
Numero di pagine9
RivistaEuropean Journal of Surgical Oncology
Stato di pubblicazionePubblicato - 2017


  • Adult
  • Aged
  • Aged, 80 and over
  • Female
  • Follow-Up Studies
  • Humans
  • Italy
  • Lymphatic Metastasis
  • Male
  • Middle Aged
  • Neo-adjuvant treatment
  • Neoadjuvant Therapy
  • Neoplasm Grading
  • Neoplasm Staging
  • Oncology
  • Pathologic complete response
  • Rectal Neoplasms
  • Rectal cancer
  • Retrospective Studies
  • Spain
  • Surgery
  • Survival Analysis
  • Treatment Outcome
  • ypT0


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