LONG-TERM NEUROPSYCHOLOGIC SEQUELAE OF CHILDHOOD LEUKEMIA - CORRELATION WITH CT BRAIN-SCAN ABNORMALITIES

Riccardo Riccardi, Pim Brouwers, Paul Fedio, David G. Poplack

Risultato della ricerca: Contributo in rivistaArticolo in rivista

130 Citazioni (Scopus)

Abstract

Previous studies have failed to establish a direct relationship between behavioral disorders and organic pathology in long-term survivors of childhood acute lymphoblastic leukemia. We evaluated 23 long-term survivors who received central nervous system preventive therapy with cranial irradiation and intrathecal chemotherapy, using neuropsychologic tests and computed tomographic brain scans. The patients were in continuous first remission for 7 to 11 years, and none were receiving chemotherapy. On the basis of their CT scan findings, they were divided into three groups: 10 with normal CT findings, five with intracerebral calcifications, and eight with cortical atrophy. Neuropsychologic test results allowed prediction of CT scan findings with an 87% accuracy (P less than 0.001), indicating a strong correlation between the presence and type of CT scan abnormality and neuropsychologic functioning. Tests that measured verbal memory, attention, and functions correlated with frontal lobe integrity were most powerful in discriminating between groups.
Lingua originaleEnglish
pagine (da-a)723-728
Numero di pagine6
RivistaJournal of Pediatrics
Volume106
DOI
Stato di pubblicazionePubblicato - 1985

Keywords

  • BRAIN-SCAN ABNORMALITIES
  • CHILDHOOD LEUKEMIA
  • NEUROPSYCHOLOGIC SEQUELAE

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