Long Term Memory Profile of Disorders Associated with Dysregulation of the RAS-MAPK Signaling Cascade.

Eugenio Maria Mercuri, Giuseppe Zampino, Maria Mallardi, Chiara Leoni, Maria Luigia Gambardella, Marco Tartaglia, Paolo Alfieri, Giorgia Piccini, Cristina Caciolo, Nadia Mirante, Francesca Pantaleoni, Maria Cristina Digilio

Risultato della ricerca: Contributo in rivistaArticolo in rivista

17 Citazioni (Scopus)

Abstract

In the present study we evaluated long term memory in twenty individuals with molecularly confirmed diagnosis of Noonan syndrome and LEOPARD syndrome, two disorders caused by mutations in genes coding transducers participating in the RAS-MAPK signaling cascade. The profile of explicit long term memory abilities was investigated using PROMEA, which includes a battery of tests specifically developed to assess memory and learning in verbal, visual and spatial domains. Ten individuals (50%) had impaired (≤5th percentile) or below average (≤15th percentile) performance on a delayed verbal free recall memory task, four (20%) on a delayed visual recognition memory task, and only one (5%) on a delayed spatial recognition memory task. Our data suggest that dysregulation of the RAS-MAPK cascade may be associated with a pattern of reduced verbal recall memory performance but relative sparing of visual and spatial recognition memory.
Lingua originaleEnglish
pagine (da-a)423-429
Numero di pagine7
RivistaBehavior Genetics
Volume2011
Stato di pubblicazionePubblicato - 2011

Keywords

  • RAS-MAPK

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