Long-term kidney function recovery and mortality after COVID-19-associated acute kidney injury: An international multi-centre observational cohort study

Byorn W L Tan; Bryce W Q Tan; Amelia L M Tan; Emily R Schriver; Alba Gutiérrez-Sacristán; Priyam Das; William Yuan; Meghan R Hutch; Noelia García Barrio; Miguel Pedrera Jimenez; Noor Abu-El-Rub; Michele Morris; Bertrand Moal; Guillaume Verdy; Kelly Cho; Yuk-Lam Ho; Lav P Patel; Arianna Dagliati; Antoine Neuraz; Jeffrey G Klann; Andrew M South; Shyam Visweswaran; David A Hanauer; Sarah E Maidlow; Mei Liu; Danielle L Mowery; Ashley Batugo; Adeline Makoudjou; Patric Tippmann; Daniela Zöller; Gabriel A Brat; Yuan Luo; Paul Avillach; Riccardo Bellazzi; Luca Chiovato; Alberto Malovini; Valentina Tibollo; Malarkodi Jebathilagam Samayamuthu; Pablo Serrano Balazote; Zongqi Xia; Ne Hooi Will Loh; Lorenzo Chiudinelli; Clara-Lea Bonzel; Chuan Hong; Harrison G Zhang; Griffin M Weber; Isaac S Kohane; Tianxi Cai; Gilbert S Omenn; John H Holmes; Kee Yuan Ngiam; Carlo Torti; Consortium for Clinical Characterization of COVID-19 by EHR (4CE)

doi:10.1016/j.eclinm.2022.101724

Long-term kidney function recovery and mortality after COVID-19-associated acute kidney injury: An international multi-centre observational cohort study

Byorn W L Tan
, Bryce W Q Tan
, Amelia L M Tan
, Emily R Schriver
, Alba Gutiérrez-Sacristán
, Priyam Das
, William Yuan
, Meghan R Hutch
, Noelia García Barrio
, Miguel Pedrera Jimenez
, Noor Abu-El-Rub
, Michele Morris
, Bertrand Moal
, Guillaume Verdy
, Kelly Cho
, Yuk-Lam Ho
, Lav P Patel
, Arianna Dagliati
, Antoine Neuraz
, Jeffrey G Klann

Andrew M South, Shyam Visweswaran, David A Hanauer, Sarah E Maidlow, Mei Liu, Danielle L Mowery, Ashley Batugo, Adeline Makoudjou, Patric Tippmann, Daniela Zöller, Gabriel A Brat, Yuan Luo, Paul Avillach, Riccardo Bellazzi, Luca Chiovato, Alberto Malovini, Valentina Tibollo, Malarkodi Jebathilagam Samayamuthu, Pablo Serrano Balazote, Zongqi Xia, Ne Hooi Will Loh, Lorenzo Chiudinelli, Clara-Lea Bonzel, Chuan Hong, Harrison G Zhang, Griffin M Weber, Isaac S Kohane, Tianxi Cai, Gilbert S Omenn, John H Holmes, Kee Yuan Ngiam^*, Carlo Torti, Consortium for Clinical Characterization of COVID-19 by EHR (4CE)

^*Autore corrispondente per questo lavoro

Risultato della ricerca: Contributo in rivista › Articolo

Abstract

Background: While acute kidney injury (AKI) is a common complication in COVID-19, data on post-AKI kidney function recovery and the clinical factors associated with poor kidney function recovery is lacking. Methods: A retrospective multi-centre observational cohort study comprising 12,891 hospitalized patients aged 18 years or older with a diagnosis of SARS-CoV-2 infection confirmed by polymerase chain reaction from 1 January 2020 to 10 September 2020, and with at least one serum creatinine value 1–365 days prior to admission. Mortality and serum creatinine values were obtained up to 10 September 2021. Findings: Advanced age (HR 2.77, 95%CI 2.53–3.04, p < 0.0001), severe COVID-19 (HR 2.91, 95%CI 2.03–4.17, p < 0.0001), severe AKI (KDIGO stage 3: HR 4.22, 95%CI 3.55–5.00, p < 0.0001), and ischemic heart disease (HR 1.26, 95%CI 1.14–1.39, p < 0.0001) were associated with worse mortality outcomes. AKI severity (KDIGO stage 3: HR 0.41, 95%CI 0.37–0.46, p < 0.0001) was associated with worse kidney function recovery, whereas remdesivir use (HR 1.34, 95%CI 1.17–1.54, p < 0.0001) was associated with better kidney function recovery. In a subset of patients without chronic kidney disease, advanced age (HR 1.38, 95%CI 1.20–1.58, p < 0.0001), male sex (HR 1.67, 95%CI 1.45–1.93, p < 0.0001), severe AKI (KDIGO stage 3: HR 11.68, 95%CI 9.80–13.91, p < 0.0001), and hypertension (HR 1.22, 95%CI 1.10–1.36, p = 0.0002) were associated with post-AKI kidney function impairment. Furthermore, patients with COVID-19-associated AKI had significant and persistent elevations of baseline serum creatinine 125% or more at 180 days (RR 1.49, 95%CI 1.32–1.67) and 365 days (RR 1.54, 95%CI 1.21–1.96) compared to COVID-19 patients with no AKI. Interpretation: COVID-19-associated AKI was associated with higher mortality, and severe COVID-19-associated AKI was associated with worse long-term post-AKI kidney function recovery. Funding: Authors are supported by various funders, with full details stated in the acknowledgement section.

Lingua originale	Inglese
pagine (da-a)	N/A-N/A
Rivista	EClinicalMedicine
Volume	55
Numero di pubblicazione	Nov
DOI	https://doi.org/10.1016/j.eclinm.2022.101724
Stato di pubblicazione	Pubblicato - 2022

All Science Journal Classification (ASJC) codes

Medicina Generale

Keywords

Acute kidney injury
COVID-19
Chronic kidney disease
Electronic health records
SARS-CoV-2

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10.1016/j.eclinm.2022.101724

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Tan, B. W. L., Tan, B. W. Q., Tan, A. L. M., Schriver, E. R., Gutiérrez-Sacristán, A., Das, P., Yuan, W., Hutch, M. R., García Barrio, N., Pedrera Jimenez, M., Abu-El-Rub, N., Morris, M., Moal, B., Verdy, G., Cho, K., Ho, Y.-L., Patel, L. P., Dagliati, A., Neuraz, A., ... (4CE), C. F. C. C. O. COVID. B. EHR. (2022). Long-term kidney function recovery and mortality after COVID-19-associated acute kidney injury: An international multi-centre observational cohort study. EClinicalMedicine, 55(Nov), N/A-N/A. https://doi.org/10.1016/j.eclinm.2022.101724

@article{1d57517baf7041c2ad1895e9a61e2a3e,

title = "Long-term kidney function recovery and mortality after COVID-19-associated acute kidney injury: An international multi-centre observational cohort study",

abstract = "Background: While acute kidney injury (AKI) is a common complication in COVID-19, data on post-AKI kidney function recovery and the clinical factors associated with poor kidney function recovery is lacking. Methods: A retrospective multi-centre observational cohort study comprising 12,891 hospitalized patients aged 18 years or older with a diagnosis of SARS-CoV-2 infection confirmed by polymerase chain reaction from 1 January 2020 to 10 September 2020, and with at least one serum creatinine value 1–365 days prior to admission. Mortality and serum creatinine values were obtained up to 10 September 2021. Findings: Advanced age (HR 2.77, 95\%CI 2.53–3.04, p < 0.0001), severe COVID-19 (HR 2.91, 95\%CI 2.03–4.17, p < 0.0001), severe AKI (KDIGO stage 3: HR 4.22, 95\%CI 3.55–5.00, p < 0.0001), and ischemic heart disease (HR 1.26, 95\%CI 1.14–1.39, p < 0.0001) were associated with worse mortality outcomes. AKI severity (KDIGO stage 3: HR 0.41, 95\%CI 0.37–0.46, p < 0.0001) was associated with worse kidney function recovery, whereas remdesivir use (HR 1.34, 95\%CI 1.17–1.54, p < 0.0001) was associated with better kidney function recovery. In a subset of patients without chronic kidney disease, advanced age (HR 1.38, 95\%CI 1.20–1.58, p < 0.0001), male sex (HR 1.67, 95\%CI 1.45–1.93, p < 0.0001), severe AKI (KDIGO stage 3: HR 11.68, 95\%CI 9.80–13.91, p < 0.0001), and hypertension (HR 1.22, 95\%CI 1.10–1.36, p = 0.0002) were associated with post-AKI kidney function impairment. Furthermore, patients with COVID-19-associated AKI had significant and persistent elevations of baseline serum creatinine 125\% or more at 180 days (RR 1.49, 95\%CI 1.32–1.67) and 365 days (RR 1.54, 95\%CI 1.21–1.96) compared to COVID-19 patients with no AKI. Interpretation: COVID-19-associated AKI was associated with higher mortality, and severe COVID-19-associated AKI was associated with worse long-term post-AKI kidney function recovery. Funding: Authors are supported by various funders, with full details stated in the acknowledgement section.",

keywords = "Acute kidney injury, COVID-19, Chronic kidney disease, Electronic health records, SARS-CoV-2, Acute kidney injury, COVID-19, Chronic kidney disease, Electronic health records, SARS-CoV-2",

author = "Tan, \{Byorn W L\} and Tan, \{Bryce W Q\} and Tan, \{Amelia L M\} and Schriver, \{Emily R\} and Alba Guti{\'e}rrez-Sacrist{\'a}n and Priyam Das and William Yuan and Hutch, \{Meghan R\} and \{Garc{\'i}a Barrio\}, Noelia and \{Pedrera Jimenez\}, Miguel and Noor Abu-El-Rub and Michele Morris and Bertrand Moal and Guillaume Verdy and Kelly Cho and Yuk-Lam Ho and Patel, \{Lav P\} and Arianna Dagliati and Antoine Neuraz and Klann, \{Jeffrey G\} and South, \{Andrew M\} and Shyam Visweswaran and Hanauer, \{David A\} and Maidlow, \{Sarah E\} and Mei Liu and Mowery, \{Danielle L\} and Ashley Batugo and Adeline Makoudjou and Patric Tippmann and Daniela Z{\"o}ller and Brat, \{Gabriel A\} and Yuan Luo and Paul Avillach and Riccardo Bellazzi and Luca Chiovato and Alberto Malovini and Valentina Tibollo and Samayamuthu, \{Malarkodi Jebathilagam\} and \{Serrano Balazote\}, Pablo and Zongqi Xia and Loh, \{Ne Hooi Will\} and Lorenzo Chiudinelli and Clara-Lea Bonzel and Chuan Hong and Zhang, \{Harrison G\} and Weber, \{Griffin M\} and Kohane, \{Isaac S\} and Tianxi Cai and Omenn, \{Gilbert S\} and Holmes, \{John H\} and Ngiam, \{Kee Yuan\} and Carlo Torti and (4CE), \{Consortium for Clinical Characterization of COVID-19 by EHR\}",

year = "2022",

doi = "10.1016/j.eclinm.2022.101724",

language = "English",

volume = "55",

pages = "N/A--N/A",

journal = "EClinicalMedicine",

issn = "2589-5370",

publisher = "Elsevier Ltd",

number = "Nov",

}

Tan, BWL, Tan, BWQ, Tan, ALM, Schriver, ER, Gutiérrez-Sacristán, A, Das, P, Yuan, W, Hutch, MR, García Barrio, N, Pedrera Jimenez, M, Abu-El-Rub, N, Morris, M, Moal, B, Verdy, G, Cho, K, Ho, Y-L, Patel, LP, Dagliati, A, Neuraz, A, Klann, JG, South, AM, Visweswaran, S, Hanauer, DA, Maidlow, SE, Liu, M, Mowery, DL, Batugo, A, Makoudjou, A, Tippmann, P, Zöller, D, Brat, GA, Luo, Y, Avillach, P, Bellazzi, R, Chiovato, L, Malovini, A, Tibollo, V, Samayamuthu, MJ, Serrano Balazote, P, Xia, Z, Loh, NHW, Chiudinelli, L, Bonzel, C-L, Hong, C, Zhang, HG, Weber, GM, Kohane, IS, Cai, T, Omenn, GS, Holmes, JH, Ngiam, KY, Torti, C & (4CE), CFCCOCOVIDBEHR 2022, 'Long-term kidney function recovery and mortality after COVID-19-associated acute kidney injury: An international multi-centre observational cohort study', EClinicalMedicine, vol. 55, n. Nov, pagg. N/A-N/A. https://doi.org/10.1016/j.eclinm.2022.101724

TY - JOUR

T1 - Long-term kidney function recovery and mortality after COVID-19-associated acute kidney injury: An international multi-centre observational cohort study

AU - Tan, Byorn W L

AU - Tan, Bryce W Q

AU - Tan, Amelia L M

AU - Schriver, Emily R

AU - Gutiérrez-Sacristán, Alba

AU - Das, Priyam

AU - Yuan, William

AU - Hutch, Meghan R

AU - García Barrio, Noelia

AU - Pedrera Jimenez, Miguel

AU - Abu-El-Rub, Noor

AU - Morris, Michele

AU - Moal, Bertrand

AU - Verdy, Guillaume

AU - Cho, Kelly

AU - Ho, Yuk-Lam

AU - Patel, Lav P

AU - Dagliati, Arianna

AU - Neuraz, Antoine

AU - Klann, Jeffrey G

AU - South, Andrew M

AU - Visweswaran, Shyam

AU - Hanauer, David A

AU - Maidlow, Sarah E

AU - Liu, Mei

AU - Mowery, Danielle L

AU - Batugo, Ashley

AU - Makoudjou, Adeline

AU - Tippmann, Patric

AU - Zöller, Daniela

AU - Brat, Gabriel A

AU - Luo, Yuan

AU - Avillach, Paul

AU - Bellazzi, Riccardo

AU - Chiovato, Luca

AU - Malovini, Alberto

AU - Tibollo, Valentina

AU - Samayamuthu, Malarkodi Jebathilagam

AU - Serrano Balazote, Pablo

AU - Xia, Zongqi

AU - Loh, Ne Hooi Will

AU - Chiudinelli, Lorenzo

AU - Bonzel, Clara-Lea

AU - Hong, Chuan

AU - Zhang, Harrison G

AU - Weber, Griffin M

AU - Kohane, Isaac S

AU - Cai, Tianxi

AU - Omenn, Gilbert S

AU - Holmes, John H

AU - Ngiam, Kee Yuan

AU - Torti, Carlo

AU - (4CE), Consortium for Clinical Characterization of COVID-19 by EHR

PY - 2022

Y1 - 2022

N2 - Background: While acute kidney injury (AKI) is a common complication in COVID-19, data on post-AKI kidney function recovery and the clinical factors associated with poor kidney function recovery is lacking. Methods: A retrospective multi-centre observational cohort study comprising 12,891 hospitalized patients aged 18 years or older with a diagnosis of SARS-CoV-2 infection confirmed by polymerase chain reaction from 1 January 2020 to 10 September 2020, and with at least one serum creatinine value 1–365 days prior to admission. Mortality and serum creatinine values were obtained up to 10 September 2021. Findings: Advanced age (HR 2.77, 95%CI 2.53–3.04, p < 0.0001), severe COVID-19 (HR 2.91, 95%CI 2.03–4.17, p < 0.0001), severe AKI (KDIGO stage 3: HR 4.22, 95%CI 3.55–5.00, p < 0.0001), and ischemic heart disease (HR 1.26, 95%CI 1.14–1.39, p < 0.0001) were associated with worse mortality outcomes. AKI severity (KDIGO stage 3: HR 0.41, 95%CI 0.37–0.46, p < 0.0001) was associated with worse kidney function recovery, whereas remdesivir use (HR 1.34, 95%CI 1.17–1.54, p < 0.0001) was associated with better kidney function recovery. In a subset of patients without chronic kidney disease, advanced age (HR 1.38, 95%CI 1.20–1.58, p < 0.0001), male sex (HR 1.67, 95%CI 1.45–1.93, p < 0.0001), severe AKI (KDIGO stage 3: HR 11.68, 95%CI 9.80–13.91, p < 0.0001), and hypertension (HR 1.22, 95%CI 1.10–1.36, p = 0.0002) were associated with post-AKI kidney function impairment. Furthermore, patients with COVID-19-associated AKI had significant and persistent elevations of baseline serum creatinine 125% or more at 180 days (RR 1.49, 95%CI 1.32–1.67) and 365 days (RR 1.54, 95%CI 1.21–1.96) compared to COVID-19 patients with no AKI. Interpretation: COVID-19-associated AKI was associated with higher mortality, and severe COVID-19-associated AKI was associated with worse long-term post-AKI kidney function recovery. Funding: Authors are supported by various funders, with full details stated in the acknowledgement section.

AB - Background: While acute kidney injury (AKI) is a common complication in COVID-19, data on post-AKI kidney function recovery and the clinical factors associated with poor kidney function recovery is lacking. Methods: A retrospective multi-centre observational cohort study comprising 12,891 hospitalized patients aged 18 years or older with a diagnosis of SARS-CoV-2 infection confirmed by polymerase chain reaction from 1 January 2020 to 10 September 2020, and with at least one serum creatinine value 1–365 days prior to admission. Mortality and serum creatinine values were obtained up to 10 September 2021. Findings: Advanced age (HR 2.77, 95%CI 2.53–3.04, p < 0.0001), severe COVID-19 (HR 2.91, 95%CI 2.03–4.17, p < 0.0001), severe AKI (KDIGO stage 3: HR 4.22, 95%CI 3.55–5.00, p < 0.0001), and ischemic heart disease (HR 1.26, 95%CI 1.14–1.39, p < 0.0001) were associated with worse mortality outcomes. AKI severity (KDIGO stage 3: HR 0.41, 95%CI 0.37–0.46, p < 0.0001) was associated with worse kidney function recovery, whereas remdesivir use (HR 1.34, 95%CI 1.17–1.54, p < 0.0001) was associated with better kidney function recovery. In a subset of patients without chronic kidney disease, advanced age (HR 1.38, 95%CI 1.20–1.58, p < 0.0001), male sex (HR 1.67, 95%CI 1.45–1.93, p < 0.0001), severe AKI (KDIGO stage 3: HR 11.68, 95%CI 9.80–13.91, p < 0.0001), and hypertension (HR 1.22, 95%CI 1.10–1.36, p = 0.0002) were associated with post-AKI kidney function impairment. Furthermore, patients with COVID-19-associated AKI had significant and persistent elevations of baseline serum creatinine 125% or more at 180 days (RR 1.49, 95%CI 1.32–1.67) and 365 days (RR 1.54, 95%CI 1.21–1.96) compared to COVID-19 patients with no AKI. Interpretation: COVID-19-associated AKI was associated with higher mortality, and severe COVID-19-associated AKI was associated with worse long-term post-AKI kidney function recovery. Funding: Authors are supported by various funders, with full details stated in the acknowledgement section.

KW - Acute kidney injury

KW - COVID-19

KW - Chronic kidney disease

KW - Electronic health records

KW - SARS-CoV-2

KW - Acute kidney injury

KW - COVID-19

KW - Chronic kidney disease

KW - Electronic health records

KW - SARS-CoV-2

UR - https://publicatt.unicatt.it/handle/10807/302879

UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85141512399&origin=inward

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85141512399&origin=inward

U2 - 10.1016/j.eclinm.2022.101724

DO - 10.1016/j.eclinm.2022.101724

M3 - Article

SN - 2589-5370

VL - 55

SP - N/A-N/A

JO - EClinicalMedicine

JF - EClinicalMedicine

IS - Nov

ER -

Long-term kidney function recovery and mortality after COVID-19-associated acute kidney injury: An international multi-centre observational cohort study

Abstract

All Science Journal Classification (ASJC) codes

Keywords

OSS delle Nazioni Unite

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