Long-Term Clinical Impact of Vesicoureteral Reflux in Kidney Transplantation

E. Favi, Gionata Spagnoletti, A. L. Valentini, V. Tondolo, Giuseppe Nanni, Franco Citterio, M. Castagneto

Risultato della ricerca: Contributo in rivistaArticolo in rivista

18 Citazioni (Scopus)


Introduction: It is unclear whether the presence of vesicoureteral reflux (VUR) after renal transplantation compromises long-term graft function. The aim of this study in renal allograft recipients with a history of late recurrent urinary tract infections (UTI) was to determine whether the presence of VUR conferred an increased risk of long-term graft dysfunction. Methods: We included 37 renal allograft recipients, who were at least 2 years after transplantation and had a history of at least 1 recurrent UTI per year underwent voiding cystourethrograms (VCUG). The presence and severity of VUR were graded with severity scores ranging from G1 to G5. Results: Of the 37 patients, 15 (41%) showed low grades of reflux (G1-3) on VCUG. Patient and graft survivals were not significantly different in the VUR group (n = 15) compared with the no VUR group (n = 22) at 1, 3, or 5 years. Renal function assessment by means of serum creatinine (Cr) concentration also demonstrated similar results in both groups at 1, 3, and 5 years: 5 y mean Cr: VUR 1.5 ± 0.6 mg/dL versus no VUR 1.8 ± 1.1 mg/dL (P = NS). No difference was also observed in the 2 groups in the number of UTI episodes for each patient per year. Conclusions: In patients with late UTIs, the presence of low-grade VUR did not affect long-term graft function. There was no indication for a operative repair of low-grade VUR. © 2009.
Lingua originaleEnglish
pagine (da-a)1218-1220
Numero di pagine3
RivistaTransplantation Proceedings
Stato di pubblicazionePubblicato - 2009


  • Adolescent
  • Adult
  • Aged
  • Allografts
  • Creatinine
  • Female
  • Graft Survival
  • Humans
  • Kidney Transplantation
  • Male
  • Middle Aged
  • Transplant Recipients
  • Vesico-Ureteral Reflux
  • Young Adult


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