Long-Term Clinical, Audiological, Visual, Neurocognitive and Behavioral Outcome in Children With Symptomatic and Asymptomatic Congenital Cytomegalovirus Infection Treated With Valganciclovir

Arianna Turriziani Colonna, Danilo Buonsenso, Davide Pata, Gilda Salerno, Daniela Pia Rosaria Chieffo, Domenico Marco Romeo, Valerio Faccia, Guido Conti, Fernando Molle, Antonio Baldascino, Chiara De Waure, Anna Acampora, Rita Paola Maria Luciano, Rosaria Santangelo, Piero Valentini

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

Abstract

Cytomegalovirus (CMV) is the most common cause of congenital infection in humans. There are no enough data on long-term outcome of newborns with congenital CMV (cCMV) infection, particularly for those asymptomatic at birth. For this reason, we performed this study to evaluate long-term audiological, visual, neurocognitive, and behavioral outcome in patients with symptomatic and asymptomatic cCMV infection treated with oral Valganciclovir (VGC). Thirty-six newborns with confirmed cCMV infection were evaluated: 12 (33.3%) symptomatic at birth and 24 asymptomatic (66.7%). No one had cognitive impairment. Cognitive assessment scales resulted abnormal in 4/35 patients (11.4%). 11/21 patients (52.4%) achieved abnormal scores in neuropsychological tests. The language evaluation gave pathological results in 6/21 (28.5%) patients. 6/35 patients (17.1%) developed SNHL, all symptomatic at birth except one. None of the 34 patients evaluated developed CMV retinopathy. Our study shows that both symptomatic and asymptomatic newborns with cCMV infection develop long-term sequelae, particularly in the behavioral and communicative areas, independently from the trimester of maternal infection.
Lingua originaleEnglish
pagine (da-a)N/A-N/A
RivistaFrontiers in Medicine
Volume7
DOI
Stato di pubblicazionePubblicato - 2020

Keywords

  • congenital cytomegalovirus
  • congenital infections
  • hearing loss
  • neurocognitive outcome
  • valganciclovir

Fingerprint

Entra nei temi di ricerca di 'Long-Term Clinical, Audiological, Visual, Neurocognitive and Behavioral Outcome in Children With Symptomatic and Asymptomatic Congenital Cytomegalovirus Infection Treated With Valganciclovir'. Insieme formano una fingerprint unica.

Cita questo