Locally injected Infliximab ameliorates murine DSS colitis: differences in serum and intestinal levels of drug between healthy and colitic mice

Loris Riccardo Lopetuso; Valentina Petito; Valerio Cufino; Vincenzo Arena; Egidio Stigliano; Viviana Gerardi; Eleonora Gaetani; Andrea Poscia; Arianna Amato; Giovanni Cammarota; Alfredo Papa; Alessandro Sgambato; Antonio Gasbarrini; Franco Scaldaferri

doi:10.1016/j.dld.2013.06.007

Locally injected Infliximab ameliorates murine DSS colitis: differences in serum and intestinal levels of drug between healthy and colitic mice

Loris Riccardo Lopetuso, Valentina Petito, Valerio Cufino, Vincenzo Arena, Egidio Stigliano, Viviana Gerardi, Eleonora Gaetani, Andrea Poscia, Arianna Amato, Giovanni Cammarota, Alfredo Papa, Alessandro Sgambato, Antonio Gasbarrini, Franco Scaldaferri

Risultato della ricerca: Contributo in rivista › Articolo in rivista › peer review

27 Citazioni (Scopus)

Abstract

Infliximab is effective in human and murine IBD, but its pharmacodynamic is still poorly known. The aim of this study was to assess the affinity of infliximab to murine TNF-α, its role in murine colitis when administered intra-rectally and its levels in the blood, gut mucosa and stool of healthy and sick mice.

Lingua originale	English
pagine (da-a)	1017-1021
Numero di pagine	5
Rivista	Digestive and Liver Disease
Volume	45
DOI	https://doi.org/10.1016/j.dld.2013.06.007
Stato di pubblicazione	Pubblicato - 2013

Keywords

Faeces
Inflammatory bowel disease
Infliximab
Intestinal mucosa
Murine DSS colitis
Pharmacokinetic
Serum levels

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10.1016/j.dld.2013.06.007

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Lopetuso, L. R., Petito, V., Cufino, V., Arena, V., Stigliano, E., Gerardi, V., Gaetani, E., Poscia, A., Amato, A., Cammarota, G., Papa, A., Sgambato, A., Gasbarrini, A., & Scaldaferri, F. (2013). Locally injected Infliximab ameliorates murine DSS colitis: differences in serum and intestinal levels of drug between healthy and colitic mice. Digestive and Liver Disease, 45, 1017-1021. https://doi.org/10.1016/j.dld.2013.06.007

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title = "Locally injected Infliximab ameliorates murine DSS colitis: differences in serum and intestinal levels of drug between healthy and colitic mice",

abstract = "Infliximab is effective in human and murine IBD, but its pharmacodynamic is still poorly known. The aim of this study was to assess the affinity of infliximab to murine TNF-α, its role in murine colitis when administered intra-rectally and its levels in the blood, gut mucosa and stool of healthy and sick mice.",

keywords = "Faeces, Inflammatory bowel disease, Infliximab, Intestinal mucosa, Murine DSS colitis, Pharmacokinetic, Serum levels, Faeces, Inflammatory bowel disease, Infliximab, Intestinal mucosa, Murine DSS colitis, Pharmacokinetic, Serum levels",

author = "Lopetuso, {Loris Riccardo} and Valentina Petito and Valerio Cufino and Vincenzo Arena and Egidio Stigliano and Viviana Gerardi and Eleonora Gaetani and Andrea Poscia and Arianna Amato and Giovanni Cammarota and Alfredo Papa and Alessandro Sgambato and Antonio Gasbarrini and Franco Scaldaferri",

year = "2013",

doi = "10.1016/j.dld.2013.06.007",

language = "English",

volume = "45",

pages = "1017--1021",

journal = "Digestive and Liver Disease",

issn = "1590-8658",

publisher = "-Roma: Editrice Gastroenterologica Italiana. -Ospedaletto Pisa: Pacini",

}

Lopetuso, LR, Petito, V, Cufino, V, Arena, V, Stigliano, E, Gerardi, V, Gaetani, E, Poscia, A, Amato, A , Cammarota, G , Papa, A , Sgambato, A , Gasbarrini, A & Scaldaferri, F 2013, 'Locally injected Infliximab ameliorates murine DSS colitis: differences in serum and intestinal levels of drug between healthy and colitic mice', Digestive and Liver Disease, vol. 45, pagg. 1017-1021. https://doi.org/10.1016/j.dld.2013.06.007

TY - JOUR

T1 - Locally injected Infliximab ameliorates murine DSS colitis: differences in serum and intestinal levels of drug between healthy and colitic mice

AU - Lopetuso, Loris Riccardo

AU - Petito, Valentina

AU - Cufino, Valerio

AU - Arena, Vincenzo

AU - Stigliano, Egidio

AU - Gerardi, Viviana

AU - Gaetani, Eleonora

AU - Poscia, Andrea

AU - Amato, Arianna

AU - Cammarota, Giovanni

AU - Papa, Alfredo

AU - Sgambato, Alessandro

AU - Gasbarrini, Antonio

AU - Scaldaferri, Franco

PY - 2013

Y1 - 2013

N2 - Infliximab is effective in human and murine IBD, but its pharmacodynamic is still poorly known. The aim of this study was to assess the affinity of infliximab to murine TNF-α, its role in murine colitis when administered intra-rectally and its levels in the blood, gut mucosa and stool of healthy and sick mice.

AB - Infliximab is effective in human and murine IBD, but its pharmacodynamic is still poorly known. The aim of this study was to assess the affinity of infliximab to murine TNF-α, its role in murine colitis when administered intra-rectally and its levels in the blood, gut mucosa and stool of healthy and sick mice.

KW - Faeces

KW - Inflammatory bowel disease

KW - Infliximab

KW - Intestinal mucosa

KW - Murine DSS colitis

KW - Pharmacokinetic

KW - Serum levels

KW - Faeces

KW - Inflammatory bowel disease

KW - Infliximab

KW - Intestinal mucosa

KW - Murine DSS colitis

KW - Pharmacokinetic

KW - Serum levels

UR - http://hdl.handle.net/10807/52243

U2 - 10.1016/j.dld.2013.06.007

DO - 10.1016/j.dld.2013.06.007

M3 - Article

SN - 1590-8658

VL - 45

SP - 1017

EP - 1021

JO - Digestive and Liver Disease

JF - Digestive and Liver Disease

ER -

Locally injected Infliximab ameliorates murine DSS colitis: differences in serum and intestinal levels of drug between healthy and colitic mice

Abstract

Keywords

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