Locally Advanced Cervical Cancer in Pregnancy

Caterina Ricci, Giovanni Scambia, Rosa Pasqualina De Vincenzo*

*Autore corrispondente per questo lavoro

Risultato della ricerca: Contributo in rivistaArticolo in rivista

14 Citazioni (Scopus)


Objective Cervical cancer is the most common gynecological cancer occurring in pregnancy, creating a complex situation both for patient and physician. Neoadjuvant chemotherapy is an innovative way of managing cervical cancer in pregnancy. Methods In our paper, we report a retrospective case series of 4 women treated with chemotherapy for invasive cervical cancer during pregnancy in our center over the last 5 years, and we summarize the available literature and guidelines. Results All the cases were locally advanced cervical cancers that received chemotherapy with platinum and/or taxanes. All patients showed a good response to chemotherapy and a radical surgery was performed with no additional morbidities at the cesarean delivery time in 3 of 4 cases. Three of 4 patients are alive and have a good outcome with no recurrence of disease up to date. One patient died because of recurrent disease 2 years after the first-line treatment during pregnancy. All babies are alive and well up to date (maximum follow-up, 63 months). Conclusions Even if there are no standardized practices in the treatment of cervical cancer in pregnancy, in our opinion, neoadjuvant chemotherapy can be a very useful strategy for patients and physicians facing the challenge.
Lingua originaleEnglish
pagine (da-a)1490-1496
Numero di pagine7
RivistaInternational Journal of Gynecological Cancer
Stato di pubblicazionePubblicato - 2016


  • Locally advanced cervical cancer
  • Neoadjuvant chemotherapy
  • Obstetrics and Gynecology
  • Oncology
  • Pregnancy


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