TY - JOUR
T1 - Locally Advanced Cervical Cancer in Pregnancy
AU - Ricci, Caterina
AU - Scambia, Giovanni
AU - De Vincenzo, Rosa Pasqualina
PY - 2016
Y1 - 2016
N2 - Objective Cervical cancer is the most common gynecological cancer occurring in pregnancy, creating a complex situation both for patient and physician. Neoadjuvant chemotherapy is an innovative way of managing cervical cancer in pregnancy. Methods In our paper, we report a retrospective case series of 4 women treated with chemotherapy for invasive cervical cancer during pregnancy in our center over the last 5 years, and we summarize the available literature and guidelines. Results All the cases were locally advanced cervical cancers that received chemotherapy with platinum and/or taxanes. All patients showed a good response to chemotherapy and a radical surgery was performed with no additional morbidities at the cesarean delivery time in 3 of 4 cases. Three of 4 patients are alive and have a good outcome with no recurrence of disease up to date. One patient died because of recurrent disease 2 years after the first-line treatment during pregnancy. All babies are alive and well up to date (maximum follow-up, 63 months). Conclusions Even if there are no standardized practices in the treatment of cervical cancer in pregnancy, in our opinion, neoadjuvant chemotherapy can be a very useful strategy for patients and physicians facing the challenge.
AB - Objective Cervical cancer is the most common gynecological cancer occurring in pregnancy, creating a complex situation both for patient and physician. Neoadjuvant chemotherapy is an innovative way of managing cervical cancer in pregnancy. Methods In our paper, we report a retrospective case series of 4 women treated with chemotherapy for invasive cervical cancer during pregnancy in our center over the last 5 years, and we summarize the available literature and guidelines. Results All the cases were locally advanced cervical cancers that received chemotherapy with platinum and/or taxanes. All patients showed a good response to chemotherapy and a radical surgery was performed with no additional morbidities at the cesarean delivery time in 3 of 4 cases. Three of 4 patients are alive and have a good outcome with no recurrence of disease up to date. One patient died because of recurrent disease 2 years after the first-line treatment during pregnancy. All babies are alive and well up to date (maximum follow-up, 63 months). Conclusions Even if there are no standardized practices in the treatment of cervical cancer in pregnancy, in our opinion, neoadjuvant chemotherapy can be a very useful strategy for patients and physicians facing the challenge.
KW - Locally advanced cervical cancer
KW - Neoadjuvant chemotherapy
KW - Obstetrics and Gynecology
KW - Oncology
KW - Pregnancy
KW - Locally advanced cervical cancer
KW - Neoadjuvant chemotherapy
KW - Obstetrics and Gynecology
KW - Oncology
KW - Pregnancy
UR - http://hdl.handle.net/10807/91740
UR - http://journals.lww.com/ijgc/pages/default.aspx
U2 - 10.1097/IGC.0000000000000795
DO - 10.1097/IGC.0000000000000795
M3 - Article
SN - 1048-891X
VL - 26
SP - 1490
EP - 1496
JO - International Journal of Gynecological Cancer
JF - International Journal of Gynecological Cancer
ER -