Abstract
The distribution and density of 3H-MPP+ binding sites were studied by in vitro quantitative autoradiography in the brain of the mouse, rat and monkey. The highest levels of 3H-MPP+ specific binding were observed in rat brain. The substantia nigra in rat and monkey, and the anterior caudate-putamen formation in mouse and monkey showed the lowest density of autoradiographic grains. The presence of a relatively high density of MPP+ sites in the hippocampus of all species studied could be of interest to explain some effects of MPTP administration on convulsions caused by chemoconvulsants. The finding of a 60-70% reduction of 3H-MPP+ binding sites in the rat caudate-putamen, on the side of quinolinic acid infusion and no changes after 6-hydroxydopamine lesion of dopaminergic nigrostriatal neurons suggests the presence of these sites mainly on striatal cells. The results suggest that the distribution of MPP+ binding sites in brain would not seem to be related to MPTP toxicity.
Lingua originale | English |
---|---|
pagine (da-a) | 181-190 |
Numero di pagine | 10 |
Rivista | JOURNAL OF NEURAL TRANSMISSION. PARKINSON'S DISEASE AND DEMENTIA SECTION |
Volume | 4 |
DOI | |
Stato di pubblicazione | Pubblicato - 1992 |
Keywords
- 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
- Animals
- Binding Sites
- Brain Chemistry
- Callithrix
- Corpus Striatum
- Female
- Image Processing, Computer-Assisted
- Male
- Mice
- Monoamine Oxidase
- Oxidopamine
- Pyridinium Compounds
- Rats
- Rats, Inbred Strains
- Species Specificity