Localization of MPP+ binding sites in the brain of various mammalian species

M. Del Zompo, M. P. Piccardi, S. Ruiu, Alberto Albanese, M. Morelli

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

5 Citazioni (Scopus)

Abstract

The distribution and density of 3H-MPP+ binding sites were studied by in vitro quantitative autoradiography in the brain of the mouse, rat and monkey. The highest levels of 3H-MPP+ specific binding were observed in rat brain. The substantia nigra in rat and monkey, and the anterior caudate-putamen formation in mouse and monkey showed the lowest density of autoradiographic grains. The presence of a relatively high density of MPP+ sites in the hippocampus of all species studied could be of interest to explain some effects of MPTP administration on convulsions caused by chemoconvulsants. The finding of a 60-70% reduction of 3H-MPP+ binding sites in the rat caudate-putamen, on the side of quinolinic acid infusion and no changes after 6-hydroxydopamine lesion of dopaminergic nigrostriatal neurons suggests the presence of these sites mainly on striatal cells. The results suggest that the distribution of MPP+ binding sites in brain would not seem to be related to MPTP toxicity.
Lingua originaleEnglish
pagine (da-a)181-190
Numero di pagine10
RivistaJOURNAL OF NEURAL TRANSMISSION. PARKINSON'S DISEASE AND DEMENTIA SECTION
Volume4
DOI
Stato di pubblicazionePubblicato - 1992

Keywords

  • 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
  • Animals
  • Binding Sites
  • Brain Chemistry
  • Callithrix
  • Corpus Striatum
  • Female
  • Image Processing, Computer-Assisted
  • Male
  • Mice
  • Monoamine Oxidase
  • Oxidopamine
  • Pyridinium Compounds
  • Rats
  • Rats, Inbred Strains
  • Species Specificity

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