Liver transplantation: the Italian experience

Maurizio Pompili, Gian Ludovico Rapaccini, Antonio Gasbarrini, Giovanni Battista Gasbarrini, S Fagiuali, Vg Mirante, S Gianni, G Leandro, R Naccarato, L Pagliaro, M Rizzetto

Risultato della ricerca: Contributo in rivistaArticolo in rivista

47 Citazioni (Scopus)

Abstract

BACKGROUND: Liver transplantation is the standard treatment for patients with end-stage liver disease no longer responsive to conventional medical treatment AIMS: To report the long-term experience of liver transplantation in Italy. PATIENTS AND METHODS: Data were obtained retrospectively by means of a multiple-item form collected from 15 Italian liver transplant centres. The filing centre was centralized. RESULTS: A total of 3323 liver transplants were performed on 3026 patients, with a cumulative proportional survival of 72.4%. Three, 5 and 10 years' patient survival rates were 72.3%, 68.8% and 61.3%, respectively. The most common indication for liver transplantation were hepatitis B virus (+/- hepatitis D virus)- and hepatitis C virus-related cirrhosis (59.4%). Excellent survival rates were observed particularly in controversial indications, such as alcoholic cirrhosis, hepatitis B virus-related cirrhosis and hepatocellular carcinoma. Retransplantation was required in 8.9% of the cases. The overall prevalence of acute cellular rejection episodes was 43.5%. In our study population, primary non-function and disease recurrence were the most common causes of graft failure (28.7% and 25.4%, respectively). Infections and/or sepsis were the most common causes of death after transplantation (42%). CONCLUSION: This study confirms that patients with controversial indications to liver transplantation such as alcoholic cirrhosis, HBV-related cirrhosis and hepatocellular carcinoma can achieve excellent survival when properly selected.
Lingua originaleEnglish
pagine (da-a)640-648
Numero di pagine9
RivistaDIGESTIVE AND LIVER DISEASE
Volume34
Stato di pubblicazionePubblicato - 2002

Keywords

  • Adolescent
  • Adult
  • Aged
  • Female
  • Graft Rejection
  • Humans
  • Italy
  • Liver Diseases
  • Liver Transplantation
  • Male
  • Middle Aged
  • Patient Selection
  • Prevalence
  • Recurrence
  • Retrospective Studies
  • Survival Rate

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