Liver transplantation in alcoholic patients: Impact of an alcohol addiction unit within a liver transplant center

Giovanni Addolorato, Giovanni Battista Gasbarrini, Salvatore Agnes, Antonio Gasbarrini, Massimo Antonelli, Alfonso Wolfango Avolio, Esmeralda Capristo, Antonio Grieco, Luca Miele, Alessandro Milani, Maurizio Pompili, Gian Ludovico Rapaccini, Gabriele Sganga, Antonio Mirijello, Cristina D'Angelo, Raffaele Landolfi, Brigida Eleonora Annicchiarico, Francesco Maria Caputo, Valentina Cesario, Francesco FrongilloDomenico Arturo Nesci, Erida Nure, Fabrizio Pizzolante, Laura Riccardi, Emanuele Rinninella, Massimo Siciliano, Vittoria Vero, Luisa Vonghia, Lorenzo Leggio, Anthony Cossari, Fabio Caputo

Risultato della ricerca: Contributo in rivistaArticolo in rivista

95 Citazioni (Scopus)

Abstract

Background: Many concerns about liver transplantation in alcoholic patients are related to the risk of alcohol recidivism. Starting from 2002, an Alcohol Addiction Unit (AAU) was formed within the liver transplant center for the management of alcoholic patients affected by end-stage liver disease and included in the waiting list for transplantation. We evaluated retrospectively the impact of the AAU on alcohol recidivism after transplantation. The relationship between alcohol recidivism and the duration of alcohol abstinence before transplant was evaluated as well. Methods: Between 1995 and 2010, 92 cirrhotic alcoholic patients underwent liver transplantation. Clinical evaluation and management of alcohol use in these patients was provided by psychiatrists with expertise in addiction medicine not affiliated to the liver transplant center before 2002 (n = 37; group A), or by the clinical staff of the AAU within the liver transplant center starting from 2002 (n = 55; group B). Results: Group B, as compared with group A, showed a significantly lower prevalence of alcohol recidivism (16.4 vs. 35.1%; p = 0.038) and a significantly lower mortality (14.5 vs. 37.8%; p = 0.01). Furthermore, an analysis of group B patients with either ≥6 or <6 months of alcohol abstinence before transplantation showed no difference in the rate of alcohol recidivism (21.1 vs. 15.4%; p = ns). Conclusions: The presence of an AAU within a liver transplant center reduces the risk of alcohol recidivism after transplantation. A pretransplant abstinence period <6 months might be considered, at least in selected patients managed by an AAU. © 2013 by the Research Society on Alcoholism.
Lingua originaleEnglish
pagine (da-a)1601-1608
Numero di pagine8
RivistaALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
Volume37
DOI
Stato di pubblicazionePubblicato - 2013

Keywords

  • Adult
  • Aged
  • Alcohol Abstinence
  • Alcohol Addiction Unit
  • Alcohol Dependence
  • Alcohol Recidivism
  • Alcoholics
  • Alcoholism
  • Baclofen
  • Female
  • Follow-Up Studies
  • Humans
  • Liver Transplantation
  • Male
  • Middle Aged
  • Orthotopic Liver Transplantation
  • Retrospective Studies
  • Substance Abuse Treatment Centers
  • Treatment Outcome

Fingerprint

Entra nei temi di ricerca di 'Liver transplantation in alcoholic patients: Impact of an alcohol addiction unit within a liver transplant center'. Insieme formano una fingerprint unica.

Cita questo