Liver transplantation for hepatitis B virus patients: long-term results of three therapeutic approaches

Alfonso Wolfango Avolio, Maurizio Pompili, Sabina Magalini, Salvatore Agnes, Erida Nure, Raffaella Barbarino, Maria Basso, Marco Castagneto, L Caccamo

Risultato della ricerca: Contributo in rivistaArticolo in rivista

20 Citazioni (Scopus)

Abstract

The indications for liver transplantation among patients with post-hepatitis B virus (HBV)-related cirrhosis have changed over the past 35 years. We reviewed the long-term results of 47 patients treated with liver transplantation for HBV-related cirrhosis. Patients were classified into 3 groups according to the perioperative regimen. In the initial experience, no immunoprophylaxis was adopted (no-IP; n=5). From 1988-1996, an immunoprophylaxis scheme was adopted (HBIg; n=16). From 1997-2007, we adopted the combination of lamivudine and HBIg (LAM-HBIg; n=26). We calculated the prevalence of serological reinfection and patient survival at 1 to 20 years, using the 3 regimens. The recurrence rate was 75% in the group of untreated patients; 30% in the HBIg group; and 9% in the LAM-HBIg group. The overall survival was 67% at 5 years, and 64% at 10 and 20 years. The long-term survival for each of the 3 therapeutic approaches, namely, for the patients who did not receive any treatment, for the HBIg group, and for the LAM-HBIg group, were 20%, 50%, and 84%, respectively. We suggest to use the LAM-HBIg combination.
Lingua originaleEnglish
pagine (da-a)1961-1964
Numero di pagine4
RivistaTransplantation Proceedings
Stato di pubblicazionePubblicato - 2008

Keywords

  • LAM-HBIg combination
  • immunoprophylaxis
  • liver transplantation
  • post-hepatitis B virus (HBV)-related cirrhosis

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