[Liver transplantation]

Maurizio Pompili, Gian Ludovico Rapaccini, Giovanni Battista Gasbarrini, Vg Mirante

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

Liver transplantation represents the first choice treatment for patients with fulminant acute hepatitis and for patients with chronic liver disease and advanced functional failure. Patients in the waiting list for liver transplantation are classified according to the severity of their clinical conditions (evaluated using staging systems mostly based on hematochemical parameters related to liver function). This classification, together with the blood group and the body size compatibility, remains the main criterion for organ allocation. The main indications for liver transplantation are cirrhosis (mainly HCV-, HBV- and alcohol-related) and hepatocellular carcinoma emerging in cirrhosis in adult patients, biliary atresia and some inborn errors of metabolism in pediatric patients. In adults the overall 5-year survival ranges between 60 and 70%, in both American and European series. Even better results have been reported for pediatric patients: in fact, the 5-year survival rate for children ranges between 70 and 80% in the main published series. In this study we evaluated the main medical problems correlated with liver transplantation such as immunosuppressive treatment, acute and chronic rejection, infectious complications, the recurrence of the liver disease leading to transplantation, and cardiovascular and metabolic complications.
Titolo tradotto del contributo[Autom. eng. transl.] [Liver transplantation]
Lingua originaleItalian
pagine (da-a)20-35
Numero di pagine16
RivistaAnnali Italiani di Medicina Interna
Volume19
Stato di pubblicazionePubblicato - 2004

Keywords

  • Adult
  • Age Factors
  • Child
  • Graft Rejection
  • Humans
  • Immunosuppression
  • Immunosuppressive Agents
  • Italy
  • Liver Cirrhosis
  • Liver Diseases
  • Liver Neoplasms
  • Liver Transplantation
  • Patient Selection
  • Postoperative Complications
  • Prognosis
  • Survival Rate

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