Liver metastasectomy for metastatic breast cancer patients: A single institution retrospective analysis

Armando Orlandi, Letizia Pontolillo, Caterina Mele, Mariangela Pasqualoni, Sergio Pannunzio, Maria Chiara Cannizzaro, Claudia Cutigni, A. Palazzo, Giovanna Garufi, Maria Vellone, Francesco Ardito, Gianluca Franceschini, A. M. Sanchez, Alessandra Cassano, Felice Giuliante, Emilio Bria, Giampaolo Tortora

Risultato della ricerca: Contributo in rivistaArticolo in rivista


The liver represents the first metastatic site in 5–12% of metastatic breast cancer (MBC) cases. In absence of reliable evidence, liver metastasectomy (LM) could represent a possible therapeutic option for selected MBC patients (patients) in clinical practice. A retrospective analysis including MBC patients who had undergone an LM after a multidisciplinary Tumor Board discussion at the Hepatobiliary Surgery Unit of Fondazione Policlinico Universitario “Agostino Gemelli” IRCCS in Rome, between January 1994 and December 2019 was conducted. The primary endpoint was overall survival (OS) after a MBC-LM; the secondary endpoint was the disease-free interval (DFI) after surgery. Forty-nine MBC patients underwent LM, but clinical data were only available for 22 patients. After a median follow-up of 71 months, median OS and DFI were 67 months (95% CI 45–103) and 15 months (95% CI 11–46), respectively. At univariate analysis, the presence of a negative resection margin (R0) was the only factor that statistically significantly influenced OS (78 months versus 16 months; HR 0.083, p < 0.0001) and DFI (16 months versus 5 months; HR 0.17, p = 0.0058). A LM for MBC might represent a therapeutic option for selected patients. The radical nature of the surgical procedure performed in a high-flow center and after a multidisciplinary discussion appears essential for this therapeutic option.
Lingua originaleEnglish
pagine (da-a)187-187
Numero di pagine10
RivistaJournal of Personalized Medicine
Stato di pubblicazionePubblicato - 2021


  • Hepatic surgery
  • Liver metastases
  • Metastatic breast cancer
  • Personalized medicine


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