Liver injury after pulsed methylprednisolone therapy in multiple sclerosis patients

Viviana Nociti, Marco Biolato, Chiara De Fino, Assunta Bianco, Francesco Antonio Losavio, Matteo Lucchini, Giuseppe Marrone, Antonio Grieco, Massimiliano Mirabella

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

8 Citazioni (Scopus)


Objectives: High-dose pulsed methylprednisolone-related liver injury cases have been reported in the literature, but a prospective study in patients with multiple sclerosis (MS) has never been performed. The aim of this study was to evaluate the prevalence and severity of liver injury in patients with MS after pulsed methylprednisolone therapy. Methods: We performed a prospective observational single-center study on patients with MS treated with i.v. methylprednisolone 1,000 mg/day for 5 days. We tested the liver functionality before and 2 weeks after the treatment. In case of severe liver injury, defined according to "Hy's law," a comprehensive hepatologic workup was performed. Results: During a 12-month observation period, we collected data on 251 cycles of i.v. steroid treatment of 175 patients with MS. After excluding eight cycles presenting a basal alteration of the biochemical liver tests, we observed a prevalence of 8.6% of liver injury in MS patients treated with pulsed methylprednisolone for clinical and neuroradiological relapses. In 2.5% of the patients, the liver injury was severe according to Hy's law; after a comprehensive hepatologic workup, three of them received a diagnosis of drug-induced liver injury and the other three of autoimmune hepatitis. Conclusions: Liver injury after pulsed methylprednisolone therapy in patients with MS is not infrequent, and a close monitoring of aminotransferase level before treatment and 2 weeks later seems advisable.
Lingua originaleEnglish
pagine (da-a)e00968-N/A
RivistaBrain and Behavior
Stato di pubblicazionePubblicato - 2018


  • Behavioral Neuroscience
  • Liver injury
  • Multiple sclerosis
  • Relapse
  • Steroids


Entra nei temi di ricerca di 'Liver injury after pulsed methylprednisolone therapy in multiple sclerosis patients'. Insieme formano una fingerprint unica.

Cita questo