Lipid synthesis from the liver in patients with psoriasis

Geltrude Mingrone, Antonio Venier, Av Greco, E Peruzzi, F. Serri

Risultato della ricerca: Contributo in rivistaArticolo in rivista

5 Citazioni (Scopus)

Abstract

In psoriatic patients with hyperlipidemia we studied the hepatic lipid synthesis from (1-(14)C)-acetate in human liver biopsy specimens in vitro by a thin-layer radio-chromatography. In psoriatics type IV (according to Fredrickson) a significant increase in (1-(14)C)-acetate hepatic incorporation especially into phospholipids (25%) and triglycerides (52%) was observed; in type IIb increased lipogenesis was phospholipids (24.5%), free cholesterol (44.4%) and triglycerides (29%). Abnormal lipid metabolism often coexists with glucose intolerance in psoriasis; no correlation between hyperinsulinemia and augmented (1-(14)C)-acetate incorporation into hepatic triglycerides was found.
Lingua originaleEnglish
pagine (da-a)271-276
Numero di pagine6
RivistaArchives of Dermatological Research
Volume268
Stato di pubblicazionePubblicato - 1980

Keywords

  • Adult
  • Humans
  • Hyperlipidemias
  • Insulin
  • Lipids
  • Liver
  • Middle Aged
  • Psoriasis

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