Linking estrogen receptor β expression with inflammatory bowel disease activity

Cristiano Spada, Angelo Mario Zullo, Luisa Guidi, Marina Pierdominici, Angela Maselli, Barbara Varano, Cristiana Barbati, Angelo Zullo, Roberto Lorenzetti, Marco Rosati, Gabriella Rainaldi, Maria Rosaria Limiti, Lucia Conti, Sandra Gessani

Risultato della ricerca: Contributo in rivistaArticolo in rivista

36 Citazioni (Scopus)

Abstract

Crohn disease (CD) and ulcerative colitis (UC) are chronic forms of inflammatory bowel disease (IBD) whose pathogenesis is only poorly understood. Estrogens have a complex role in inflammation and growing evidence suggests that these hormones may impact IBD pathogenesis. Here, we demonstrated a significant reduction (p < 0.05) of estrogen receptor (ER)β expression in peripheral blood T lymphocytes from CD/UC patients with active disease (n = 27) as compared to those in remission (n = 21) and healthy controls (n = 29). Accordingly, in a subgroup of CD/UC patients undergoing to anti-TNF-α therapy and responsive to treatment, ERβ expression was higher (p < 0.01) than that observed in not responsive patients and comparable to that of control subjects. Notably, ERβ expression was markedly decreased in colonic mucosa of CD/UC patients with active disease, reflecting the alterations observed in peripheral blood T cells. ERβ expression inversely correlated with interleukin (IL)-6 serum levels and exogenous exposure of both T lymphocytes and intestinal epithelial cells to this cytokine resulted in ERβ downregulation. These results demonstrate that the ER profile is altered in active IBD patients at both mucosal and systemic levels, at least in part due to IL-6 dysregulation, and highlight the potential exploitation of T cell-associated ERβ as a biomarker of endoscopic disease activity.
Lingua originaleEnglish
pagine (da-a)40443-40451
Numero di pagine9
RivistaOncotarget
Volume6
DOI
Stato di pubblicazionePubblicato - 2015

Keywords

  • Adult
  • Aged
  • Antibodies, Monoclonal
  • Blotting, Western
  • Caco-2 Cells
  • Case-Control Studies
  • Cell Proliferation
  • Colon
  • Cytokines
  • Enzyme-Linked Immunosorbent Assay
  • Epithelial Cells
  • Estrogen Receptor beta
  • Estrogen receptors
  • Female
  • Humans
  • Immune response
  • Immunity
  • Immunoenzyme Techniques
  • Immunology and Microbiology Section
  • Inflammation
  • Inflammatory Bowel Diseases
  • Inflammatory bowel disease
  • Intestinal Mucosa
  • Male
  • Middle Aged
  • Prognosis
  • Remission Induction
  • T lymphocytes
  • T-Lymphocytes
  • Tumor Necrosis Factor-alpha
  • Young Adult

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