Linezolid plasma and intrapulmonary concentrations in critically ill obese patients with ventilator-associated pneumonia: intermittent vs continuous administration

Gennaro De Pascale; S Fortuna; Mario Tumbarello; Sl Cutuli; Maria Sole Vallecoccia; Teresa Spanu; Giuseppe Bello; Luca Montini; Mariano Alberto Pennisi; Pierluigi Navarra; Massimo Antonelli

doi:10.1007/s00134-014-3550-y

Linezolid plasma and intrapulmonary concentrations in critically ill obese patients with ventilator-associated pneumonia: intermittent vs continuous administration

Gennaro De Pascale, S Fortuna, Mario Tumbarello, Sl Cutuli, Maria Sole Vallecoccia, Teresa Spanu, Giuseppe Bello, Luca Montini, Mariano Alberto Pennisi, Pierluigi Navarra, Massimo Antonelli

Risultato della ricerca: Contributo in rivista › Articolo

25 Citazioni (Scopus)

Abstract

Clinical application of an antibiotic's pharmacokinetic/pharmacodynamic (PK/PD) properties may improve the outcome of severe infections. No data are available on the use of linezolid (LNZ) continuous infusion in critically ill obese patients affected by ventilator-associated pneumonia (VAP).

Lingua originale	Inglese
pagine (da-a)	103-110
Numero di pagine	8
Rivista	Intensive Care Medicine
Volume	41
Numero di pubblicazione	1
DOI	https://doi.org/10.1007/s00134-014-3550-y
Stato di pubblicazione	Pubblicato - 2015

All Science Journal Classification (ASJC) codes

Terapia Intensiva e Rianimazione

Keywords

Acetamides
Aged
Anti-Bacterial Agents
Critical Illness
Drug Monitoring
Female
Humans
Infusions
Intravenous
Linezolid
Male
Microbial Sensitivity Tests
Middle Aged
Obesity
Organ Dysfunction Scores
Oxazolidinones
Pneumonia
Prospective Studies
Risk Assessment
Rome
Ventilator-Associated

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10.1007/s00134-014-3550-y

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De Pascale, G., Fortuna, S., Tumbarello, M., Cutuli, S., Vallecoccia, M. S., Spanu, T., Bello, G., Montini, L., Pennisi, M. A., Navarra, P., & Antonelli, M. (2015). Linezolid plasma and intrapulmonary concentrations in critically ill obese patients with ventilator-associated pneumonia: intermittent vs continuous administration. Intensive Care Medicine, 41(1), 103-110. https://doi.org/10.1007/s00134-014-3550-y

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title = "Linezolid plasma and intrapulmonary concentrations in critically ill obese patients with ventilator-associated pneumonia: intermittent vs continuous administration",

abstract = "Clinical application of an antibiotic's pharmacokinetic/pharmacodynamic (PK/PD) properties may improve the outcome of severe infections. No data are available on the use of linezolid (LNZ) continuous infusion in critically ill obese patients affected by ventilator-associated pneumonia (VAP).",

keywords = "Acetamides, Aged, Anti-Bacterial Agents, Critical Illness, Drug Monitoring, Female, Humans, Infusions, Intravenous, Linezolid, Male, Microbial Sensitivity Tests, Middle Aged, Obesity, Organ Dysfunction Scores, Oxazolidinones, Pneumonia, Prospective Studies, Risk Assessment, Rome, Ventilator-Associated, Acetamides, Aged, Anti-Bacterial Agents, Critical Illness, Drug Monitoring, Female, Humans, Infusions, Intravenous, Linezolid, Male, Microbial Sensitivity Tests, Middle Aged, Obesity, Organ Dysfunction Scores, Oxazolidinones, Pneumonia, Prospective Studies, Risk Assessment, Rome, Ventilator-Associated",

author = "\{De Pascale\}, Gennaro and S Fortuna and Mario Tumbarello and Sl Cutuli and Vallecoccia, \{Maria Sole\} and Teresa Spanu and Giuseppe Bello and Luca Montini and Pennisi, \{Mariano Alberto\} and Pierluigi Navarra and Massimo Antonelli",

year = "2015",

doi = "10.1007/s00134-014-3550-y",

language = "English",

volume = "41",

pages = "103--110",

journal = "Intensive Care Medicine",

issn = "0342-4642",

publisher = "Springer Science and Business Media Deutschland GmbH",

number = "1",

}

De Pascale, G, Fortuna, S, Tumbarello, M, Cutuli, S, Vallecoccia, MS, Spanu, T, Bello, G, Montini, L , Pennisi, MA , Navarra, P & Antonelli, M 2015, 'Linezolid plasma and intrapulmonary concentrations in critically ill obese patients with ventilator-associated pneumonia: intermittent vs continuous administration', Intensive Care Medicine, vol. 41, n. 1, pagg. 103-110. https://doi.org/10.1007/s00134-014-3550-y

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AU - De Pascale, Gennaro

AU - Fortuna, S

AU - Tumbarello, Mario

AU - Cutuli, Sl

AU - Vallecoccia, Maria Sole

AU - Spanu, Teresa

AU - Bello, Giuseppe

AU - Montini, Luca

AU - Pennisi, Mariano Alberto

AU - Navarra, Pierluigi

AU - Antonelli, Massimo

PY - 2015

Y1 - 2015

N2 - Clinical application of an antibiotic's pharmacokinetic/pharmacodynamic (PK/PD) properties may improve the outcome of severe infections. No data are available on the use of linezolid (LNZ) continuous infusion in critically ill obese patients affected by ventilator-associated pneumonia (VAP).

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KW - Linezolid

KW - Male

KW - Microbial Sensitivity Tests

KW - Middle Aged

KW - Obesity

KW - Organ Dysfunction Scores

KW - Oxazolidinones

KW - Pneumonia

KW - Prospective Studies

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Linezolid plasma and intrapulmonary concentrations in critically ill obese patients with ventilator-associated pneumonia: intermittent vs continuous administration

Abstract

All Science Journal Classification (ASJC) codes

Keywords

OSS delle Nazioni Unite

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