Linezolid plasma and intrapulmonary concentrations in critically ill obese patients with ventilator-associated pneumonia: intermittent vs continuous administration

Gennaro De Pascale, Serena Fortuna, Mario Tumbarello, Salvatore Lucio Cutuli, Maria Sole Vallecoccia, Teresa Spanu, Giuseppe Bello, Luca Montini, Mariano Alberto Pennisi, Pierluigi Navarra, Massimo Antonelli

Risultato della ricerca: Contributo in rivistaArticolo in rivista

25 Citazioni (Scopus)

Abstract

Clinical application of an antibiotic's pharmacokinetic/pharmacodynamic (PK/PD) properties may improve the outcome of severe infections. No data are available on the use of linezolid (LNZ) continuous infusion in critically ill obese patients affected by ventilator-associated pneumonia (VAP).
Lingua originaleEnglish
pagine (da-a)103-110
Numero di pagine8
RivistaIntensive Care Medicine
Volume41
DOI
Stato di pubblicazionePubblicato - 2015

Keywords

  • Acetamides
  • Aged
  • Anti-Bacterial Agents
  • Critical Illness
  • Drug Monitoring
  • Female
  • Humans
  • Infusions, Intravenous
  • Linezolid
  • Male
  • Microbial Sensitivity Tests
  • Middle Aged
  • Obesity
  • Organ Dysfunction Scores
  • Oxazolidinones
  • Pneumonia, Ventilator-Associated
  • Prospective Studies
  • Risk Assessment
  • Rome

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