Linear IgA bullous dermatosis after contact with sodium hypochlorite

R Pellicano, M Lomuto, E Cozzani, M Iannantuono, Clara De Simone

Risultato della ricerca: Contributo in rivistaArticolo in rivista

12 Citazioni (Scopus)


The onset of linear IgA bullous dermatosis (LABD) is generally spontaneous, but a number of cases of LABD have been reported either following drug exposure or in association with malignancies. We describe a patient who developed a vesicular eruption shortly after an irritant dermatitis caused by the contact with a detergent containing sodium hypochlorite. Direct immunofluorescence revealed linear deposits of IgA and C3 in the epidermal basement membrane. The patient's serum contained IgA that immunoblotted a 180-kD polypeptide in extracts of human keratinocytes. The patient responded promptly to therapy with dapsone. We suggest a possible pathogenetic relationship between the chemical dermatitis and LABD in this patient.
Lingua originaleEnglish
pagine (da-a)284-286
Numero di pagine3
Stato di pubblicazionePubblicato - 1997


  • Adult
  • Basement Membrane
  • Complement C3
  • Dapsone
  • Dermatitis, Irritant
  • Detergents
  • Disinfectants
  • Epidermis
  • Female
  • Fluorescent Antibody Technique, Direct
  • Folic Acid Antagonists
  • Humans
  • Immunoblotting
  • Immunoglobulin A
  • Keratinocytes
  • Skin Diseases, Vesiculobullous
  • Sodium Hypochlorite


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