Line-field confocal optical coherence tomography of basosquamous carcinoma: a case series with histopathological correlation

Simone Cappilli, E. Cinotti, C. Lenoir, L. Tognetti, J. Perez-Anker, P. Rubegni, S. Puig, J. Malvehy, J. L. Perrot, V. Del Marmol, Ketty Peris, M. Suppa

Risultato della ricerca: Contributo in rivistaArticolo in rivista


Background: Basosquamous carcinoma (BSC) is a rare and potentially aggressive cutaneous neoplasm combining histopathological features of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). Line-field confocal optical coherence tomography (LC-OCT) is a new, non-invasive imaging technique featuring excellent resolution and penetration. To date, studies about the use of LC-OCT in the BCC and SCC fields are available, but similar investigations are lacking in the BSC field. Objective: The goal of the present study was to identify/describe LC-OCT criteria of BSC. Methods: Consecutively enrolled BSCs were imaged with dermoscopy and LC-OCT prior to surgical excision. Dermoscopic and LC-OCT images were evaluated, and histopathological slides were reviewed. Results: Six BSCs from six patients [four (66.7%) males and two (33.3%) females; mean age 76.5 (62–96) years] were included. Identified LC-OCT criteria for BSC included BCC-associated (dermal lobules with millefeuille pattern, dilated vessels, bright cells within the epidermis, bright cells within lobules, stromal stretching, stromal brightness) and SCC-associated features (acanthosis, hyperkeratosis, disarranged epidermal architecture, broad strands, elastosis and glomerular vessels). Interruption of the dermal–epidermal junction and ulceration represented overlapping criteria. Conclusion: Line-field confocal-OCT is a new promising technique that may support the non-invasive recognition of BSC through the simultaneous detection of BCC-associated and SCC-associated features. We hypothesize that the use of LC-OCT might be helpful not only in the diagnostic setting but also in the follow-up surveillance for an early identification of recurrences. Further larger studies are needed to prove this hypothesis.
Lingua originaleEnglish
pagine (da-a)N/A-N/A
RivistaJournal of the European Academy of Dermatology and Venereology
Stato di pubblicazionePubblicato - 2022


  • Line-field confocal optical coherence tomography


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