Abstract

Plant polyphenols are a broad group of bioactive compounds characterized by dierent chemical and structural properties, low bioavailability, and several in vitro biological activities. Among these compounds, lignans (a non-flavonoid polyphenolic class found in plant foods for human nutrition) have been recently studied as potential modulators of the gut–brain axis. In particular, gut bacterial metabolism is able to convert dietary lignans into therapeutically relevant polyphenols (i.e., enterolignans), such as enterolactone and enterodiol. Enterolignans are characterized by various biologic activities, including tissue-specific estrogen receptor activation, together with anti-inflammatory and apoptotic eects. However, variation in enterolignans production by the gut microbiota is strictly related to both bioaccessibility and bioavailability of lignans through the entire gastrointestinal tract. Therefore, in this review, we summarized the most important dietary source of lignans, exploring the
Lingua originaleEnglish
pagine (da-a)1-17
Numero di pagine17
RivistaMolecules
Volume2020
Stato di pubblicazionePubblicato - 2020

Keywords

  • bioaccessibility
  • enterolignans
  • gut microbiota
  • gut–brain axis
  • phenolic compounds

Fingerprint

Entra nei temi di ricerca di 'Lignans and Gut Microbiota: An Interplay Revealing Potential Health Implications'. Insieme formano una fingerprint unica.

Cita questo