TY - JOUR
T1 - Life-Threatening Arrhythmias in Patients With Takotsubo Syndrome Insights Into Pathophysiology and Treatment Innovations
AU - La Vecchia, Giulia
AU - Del Buono, Marco Giuseppe
AU - Sanna, Tommaso
AU - Capecchi, Pier Leopoldo
AU - Lazzerini, Pietro Enea
AU - Golino, Michele
AU - Kron, Jordana
AU - Rodriguez-Miguelez, Paula
AU - Pelargonio, Gemma
AU - Abbate, Antonio
PY - 2024
Y1 - 2024
N2 - Takotsubo syndrome (TTS) is a reversible form of acute myocardial injury due to a neurocardiogenic mechanism associated with a relevant risk for life-threatening ventricular arrhythmias, occurring in up to 25% of all patients and including both ventricular arrhythmias (especially) in the context of QT prolongation and atrial tachy- or bradyarrhythmias. The pathogenetic mechanisms of TTS-related arrhythmic complications are not completely understood, and there are no randomized clinical trials addressing the pharmacologic and nonpharmacologic management in this specific setting. In this narrative review, the authors provide an overview of the pathogenesis and the therapeutic management of arrhythmic complications in patients with TTS, along with the future perspectives and the remaining knowledge gaps in this field. (JACC Clin Electrophysiol 2024;10:1943-1952) (c) 2024 by the American College of Cardiology Foundation.
AB - Takotsubo syndrome (TTS) is a reversible form of acute myocardial injury due to a neurocardiogenic mechanism associated with a relevant risk for life-threatening ventricular arrhythmias, occurring in up to 25% of all patients and including both ventricular arrhythmias (especially) in the context of QT prolongation and atrial tachy- or bradyarrhythmias. The pathogenetic mechanisms of TTS-related arrhythmic complications are not completely understood, and there are no randomized clinical trials addressing the pharmacologic and nonpharmacologic management in this specific setting. In this narrative review, the authors provide an overview of the pathogenesis and the therapeutic management of arrhythmic complications in patients with TTS, along with the future perspectives and the remaining knowledge gaps in this field. (JACC Clin Electrophysiol 2024;10:1943-1952) (c) 2024 by the American College of Cardiology Foundation.
KW - QT prolongation
KW - arrhythmias
KW - autonomic modulation
KW - stress cardiomyopathy
KW - QT prolongation
KW - arrhythmias
KW - autonomic modulation
KW - stress cardiomyopathy
UR - http://hdl.handle.net/10807/304639
U2 - 10.1016/j.jacep.2024.03.034
DO - 10.1016/j.jacep.2024.03.034
M3 - Article
SN - 2405-5018
VL - 10
SP - 1943
EP - 1952
JO - JACC: Clinical Electrophysiology
JF - JACC: Clinical Electrophysiology
ER -