Left Main Trifurcation and Its Percutaneous Treatment: What Is Known so Far?

Mila Kovacevic, Francesco Burzotta, Sameh Elharty, George Besis, Cristina Aurigemma, Enrico Romagnoli, Carlo Trani

Risultato della ricerca: Contributo in rivistaArticolo in rivista


In humans, the most common anatomic variation of the left main (LM) stem is represented by its distal division in 3 branches (LM trifurcation) instead of 2. LM trifurcation disease accounts for ≈10% to 15% of all LM diseases and is often managed by cardiac surgery. Over the last decades, due to the improvement of interventional material and techniques, percutaneous coronary intervention started gaining acceptance to treat patients with LM disease including those with trifurcated anatomy. Yet, LM trifurcation stenosis with its intrinsic anatomic complexity (3 branches, at least 4 angles, wide variability in branch size and disease) is recognized as a challenging lesion subset for percutaneous coronary intervention. In this review, we summarize available data about LM trifurcation anatomy, its influence on percutaneous coronary intervention feasibility, and the evidence collected regarding the different technical options (including trissing balloon inflation).
Lingua originaleEnglish
pagine (da-a)356-363
Numero di pagine8
Stato di pubblicazionePubblicato - 2021


  • anatomic variation
  • coronary artery disease
  • feasibility studies
  • percutaneous coronary intervention
  • precision medicine


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