TY - JOUR
T1 - Lateral inhibition in the somatosensory cortex during and between migraine without aura attacks: Correlations with thalamocortical activity and clinical features
AU - Evangelista, Maurizio
AU - Coppola, Gianluca
AU - Bracaglia, Martina
AU - Di Lenola, Davide
AU - Iacovelli, Elisa
AU - Di Lorenzo, Cherubino
AU - Serrao, Mariano
AU - Parisi, Vincenzo
AU - Schoenen, Jean
AU - Pierelli, Francesco
PY - 2015
Y1 - 2015
N2 - Background We studied lateral inhibition in the somatosensory cortex of migraineurs during and between attacks, and searched for correlations with thalamocortical activity and clinical features.
Participants and methods Somatosensory evoked potentials (SSEP) were obtained by electrical stimulation of the right median (M) or ulnar (U) nerves at the wrist or by simultaneous stimulation of both nerves (MU) in 41 migraine without aura patients, 24 between (MO), 17 during attacks, and in 17 healthy volunteers (HVs). We determined the percentage of lateral inhibition of the N20–P25 component by using the formula [(100)–MU/(M + U)*100]. We also studied high-frequency oscillations (HFOs) reflecting thalamocortical activation.
Results In migraine, both lateral inhibition (MO 27.9% vs HVs 40.2%; p = 0.009) and thalamocortical activity (MO 0.5 vs HVs 0.7; p = 0.02) were reduced between attacks, but not during. In MO patients, the percentage of lateral inhibition negatively correlated with days elapsed since the last migraine attack (r = −0.510, p = 0.01), monthly attack duration (r = −0.469, p = 0.02) and severity (r = −0.443, p = 0.03), but positively with thalamocortical activity (r = −0.463, p = 0.02).
Conclusions We hypothesize that abnormal migraine cycle-dependent dynamics of connectivity between subcortical and cortical excitation/inhibition networks may contribute to clinical features of MO and recurrence of attacks.
AB - Background We studied lateral inhibition in the somatosensory cortex of migraineurs during and between attacks, and searched for correlations with thalamocortical activity and clinical features.
Participants and methods Somatosensory evoked potentials (SSEP) were obtained by electrical stimulation of the right median (M) or ulnar (U) nerves at the wrist or by simultaneous stimulation of both nerves (MU) in 41 migraine without aura patients, 24 between (MO), 17 during attacks, and in 17 healthy volunteers (HVs). We determined the percentage of lateral inhibition of the N20–P25 component by using the formula [(100)–MU/(M + U)*100]. We also studied high-frequency oscillations (HFOs) reflecting thalamocortical activation.
Results In migraine, both lateral inhibition (MO 27.9% vs HVs 40.2%; p = 0.009) and thalamocortical activity (MO 0.5 vs HVs 0.7; p = 0.02) were reduced between attacks, but not during. In MO patients, the percentage of lateral inhibition negatively correlated with days elapsed since the last migraine attack (r = −0.510, p = 0.01), monthly attack duration (r = −0.469, p = 0.02) and severity (r = −0.443, p = 0.03), but positively with thalamocortical activity (r = −0.463, p = 0.02).
Conclusions We hypothesize that abnormal migraine cycle-dependent dynamics of connectivity between subcortical and cortical excitation/inhibition networks may contribute to clinical features of MO and recurrence of attacks.
KW - MIGRAINE
KW - somatosensory cortex
KW - thalamocortical activity
KW - MIGRAINE
KW - somatosensory cortex
KW - thalamocortical activity
UR - http://hdl.handle.net/10807/69490
UR - http://dx.medra.org/10.1177/0333102415610873
U2 - 10.1177/0333102415610873
DO - 10.1177/0333102415610873
M3 - Article
SP - N/A-N/A
JO - Cephalalgia
JF - Cephalalgia
SN - 0333-1024
ER -