Late-life Enalapril administration induces nitric oxide-dependent and independent metabolic adaptations in the rat skeletal muscle

Emanuele Marzetti; Riccardo Calvani; J. DuPree; H. A. Lees; Silvia Giovannini; Seo D. -O.; T. W. Buford; K. Sweet; D. Morgan; K. Y. E. Strehler; D. Diz; S. E. Borst; N. Moningka; K. Krotova; C. S. Carter

doi:10.1007/s11357-012-9428-4

Late-life Enalapril administration induces nitric oxide-dependent and independent metabolic adaptations in the rat skeletal muscle

Emanuele Marzetti, Riccardo Calvani, J. DuPree, H. A. Lees, Silvia Giovannini, Seo D. -O., T. W. Buford, K. Sweet, D. Morgan, K. Y. E. Strehler, D. Diz, S. E. Borst, N. Moningka, K. Krotova, C. S. Carter^*

^*Autore corrispondente per questo lavoro

Risultato della ricerca: Contributo in rivista › Articolo › peer review

Abstract

Recently, we showed that administration of the angiotensin-converting enzyme inhibitor enalapril to aged rats attenuated muscle strength decline and mitigated apoptosis in the gastrocnemius muscle. The aimof the present study was to investigate possible mechanisms underlying the muscle-protective effects of enalapril. We also sought to discern the effects of enalapril mediated by nitric oxide (NO) from those independent mediated by mitigation of oxidative stress and proinflammatory signaling. © American Aging Association 2012.

Lingua originale	Inglese
pagine (da-a)	1061-1075
Numero di pagine	15
Rivista	Age
Volume	35
Numero di pubblicazione	4
DOI	https://doi.org/10.1007/s11357-012-9428-4
Stato di pubblicazione	Pubblicato - 2013

All Science Journal Classification (ASJC) codes

Invecchiamento
Geriatria e Gerontologia

Keywords

ACE inhibitors
Aging
Glucose tolerance
Inflammation
L-NAME
MTOR
Mitochondria
Nitric oxide synthase (NOS) isoforms

Accesso al documento

10.1007/s11357-012-9428-4

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Marzetti, E., Calvani, R., DuPree, J., Lees, H. A., Giovannini, S., -O., S. D., Buford, T. W., Sweet, K., Morgan, D., Strehler, K. Y. E., Diz, D., Borst, S. E., Moningka, N., Krotova, K., & Carter, C. S. (2013). Late-life Enalapril administration induces nitric oxide-dependent and independent metabolic adaptations in the rat skeletal muscle. Age, 35(4), 1061-1075. https://doi.org/10.1007/s11357-012-9428-4

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title = "Late-life Enalapril administration induces nitric oxide-dependent and independent metabolic adaptations in the rat skeletal muscle",

abstract = "Recently, we showed that administration of the angiotensin-converting enzyme inhibitor enalapril to aged rats attenuated muscle strength decline and mitigated apoptosis in the gastrocnemius muscle. The aimof the present study was to investigate possible mechanisms underlying the muscle-protective effects of enalapril. We also sought to discern the effects of enalapril mediated by nitric oxide (NO) from those independent mediated by mitigation of oxidative stress and proinflammatory signaling. {\textcopyright} American Aging Association 2012.",

keywords = "ACE inhibitors, Aging, Glucose tolerance, Inflammation, L-NAME, MTOR, Mitochondria, Nitric oxide synthase (NOS) isoforms, ACE inhibitors, Aging, Glucose tolerance, Inflammation, L-NAME, MTOR, Mitochondria, Nitric oxide synthase (NOS) isoforms",

author = "Emanuele Marzetti and Riccardo Calvani and J. DuPree and Lees, \{H. A.\} and Silvia Giovannini and -O., \{Seo D.\} and Buford, \{T. W.\} and K. Sweet and D. Morgan and Strehler, \{K. Y. E.\} and D. Diz and Borst, \{S. E.\} and N. Moningka and K. Krotova and Carter, \{C. S.\}",

year = "2013",

doi = "10.1007/s11357-012-9428-4",

language = "English",

volume = "35",

pages = "1061--1075",

journal = "Age",

issn = "0161-9152",

publisher = "Springer Netherlands",

number = "4",

}

Marzetti, E , Calvani, R, DuPree, J, Lees, HA, Giovannini, S, -O., SD, Buford, TW, Sweet, K, Morgan, D, Strehler, KYE, Diz, D, Borst, SE, Moningka, N, Krotova, K & Carter, CS 2013, 'Late-life Enalapril administration induces nitric oxide-dependent and independent metabolic adaptations in the rat skeletal muscle', Age, vol. 35, n. 4, pagg. 1061-1075. https://doi.org/10.1007/s11357-012-9428-4

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AU - Marzetti, Emanuele

AU - Calvani, Riccardo

AU - DuPree, J.

AU - Lees, H. A.

AU - Giovannini, Silvia

AU - -O., Seo D.

AU - Buford, T. W.

AU - Sweet, K.

AU - Morgan, D.

AU - Strehler, K. Y. E.

AU - Diz, D.

AU - Borst, S. E.

AU - Moningka, N.

AU - Krotova, K.

AU - Carter, C. S.

PY - 2013

Y1 - 2013

N2 - Recently, we showed that administration of the angiotensin-converting enzyme inhibitor enalapril to aged rats attenuated muscle strength decline and mitigated apoptosis in the gastrocnemius muscle. The aimof the present study was to investigate possible mechanisms underlying the muscle-protective effects of enalapril. We also sought to discern the effects of enalapril mediated by nitric oxide (NO) from those independent mediated by mitigation of oxidative stress and proinflammatory signaling. © American Aging Association 2012.

AB - Recently, we showed that administration of the angiotensin-converting enzyme inhibitor enalapril to aged rats attenuated muscle strength decline and mitigated apoptosis in the gastrocnemius muscle. The aimof the present study was to investigate possible mechanisms underlying the muscle-protective effects of enalapril. We also sought to discern the effects of enalapril mediated by nitric oxide (NO) from those independent mediated by mitigation of oxidative stress and proinflammatory signaling. © American Aging Association 2012.

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KW - Aging

KW - Glucose tolerance

KW - Inflammation

KW - L-NAME

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KW - Nitric oxide synthase (NOS) isoforms

KW - ACE inhibitors

KW - Aging

KW - Glucose tolerance

KW - Inflammation

KW - L-NAME

KW - MTOR

KW - Mitochondria

KW - Nitric oxide synthase (NOS) isoforms

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ER -

Late-life Enalapril administration induces nitric oxide-dependent and independent metabolic adaptations in the rat skeletal muscle

Abstract

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Keywords

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