Late-life Enalapril administration induces nitric oxide-dependent and independent metabolic adaptations in the rat skeletal muscle

Emanuele Marzetti; Riccardo Calvani; Jameson Dupree; Hazel A. Lees; Silvia Giovannini; Dong-Oh Seo; Thomas W. Buford; Kindal Sweet; Drake Morgan; Kevin Y. E. Strehler; Debra Diz; Stephen E. Borst; Natasha Moningka; Karina Krotova; Christy S. Carter

doi:10.1007/s11357-012-9428-4

Late-life Enalapril administration induces nitric oxide-dependent and independent metabolic adaptations in the rat skeletal muscle

Emanuele Marzetti, Riccardo Calvani, Jameson Dupree, Hazel A. Lees, Silvia Giovannini, Dong-Oh Seo, Thomas W. Buford, Kindal Sweet, Drake Morgan, Kevin Y. E. Strehler, Debra Diz, Stephen E. Borst, Natasha Moningka, Karina Krotova, Christy S. Carter

Risultato della ricerca: Contributo in rivista › Articolo in rivista

Abstract

Recently, we showed that administration of the angiotensin-converting enzyme inhibitor enalapril to aged rats attenuated muscle strength decline and mitigated apoptosis in the gastrocnemius muscle. The aimof the present study was to investigate possible mechanisms underlying the muscle-protective effects of enalapril. We also sought to discern the effects of enalapril mediated by nitric oxide (NO) from those independent mediated by mitigation of oxidative stress and proinflammatory signaling. © American Aging Association 2012.

Lingua originale	English
pagine (da-a)	1061-1075
Numero di pagine	15
Rivista	Age
Volume	35
DOI	https://doi.org/10.1007/s11357-012-9428-4
Stato di pubblicazione	Pubblicato - 2013

Keywords

ACE inhibitors
Aging
Glucose tolerance
Inflammation
L-NAME
MTOR
Mitochondria
Nitric oxide synthase (NOS) isoforms

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10.1007/s11357-012-9428-4

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Marzetti, E., Calvani, R., Dupree, J., Lees, H. A., Giovannini, S., Seo, D.-O., Buford, T. W., Sweet, K., Morgan, D., Strehler, K. Y. E., Diz, D., Borst, S. E., Moningka, N., Krotova, K., & Carter, C. S. (2013). Late-life Enalapril administration induces nitric oxide-dependent and independent metabolic adaptations in the rat skeletal muscle. Age, 35, 1061-1075. https://doi.org/10.1007/s11357-012-9428-4

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title = "Late-life Enalapril administration induces nitric oxide-dependent and independent metabolic adaptations in the rat skeletal muscle",

abstract = "Recently, we showed that administration of the angiotensin-converting enzyme inhibitor enalapril to aged rats attenuated muscle strength decline and mitigated apoptosis in the gastrocnemius muscle. The aimof the present study was to investigate possible mechanisms underlying the muscle-protective effects of enalapril. We also sought to discern the effects of enalapril mediated by nitric oxide (NO) from those independent mediated by mitigation of oxidative stress and proinflammatory signaling. {\textcopyright} American Aging Association 2012.",

keywords = "ACE inhibitors, Aging, Glucose tolerance, Inflammation, L-NAME, MTOR, Mitochondria, Nitric oxide synthase (NOS) isoforms, ACE inhibitors, Aging, Glucose tolerance, Inflammation, L-NAME, MTOR, Mitochondria, Nitric oxide synthase (NOS) isoforms",

author = "Emanuele Marzetti and Riccardo Calvani and Jameson Dupree and Lees, {Hazel A.} and Silvia Giovannini and Dong-Oh Seo and Buford, {Thomas W.} and Kindal Sweet and Drake Morgan and Strehler, {Kevin Y. E.} and Debra Diz and Borst, {Stephen E.} and Natasha Moningka and Karina Krotova and Carter, {Christy S.}",

year = "2013",

doi = "10.1007/s11357-012-9428-4",

language = "English",

volume = "35",

pages = "1061--1075",

journal = "Age",

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publisher = "Springer Netherlands",

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Marzetti, E , Calvani, R, Dupree, J, Lees, HA, Giovannini, S, Seo, D-O, Buford, TW, Sweet, K, Morgan, D, Strehler, KYE, Diz, D, Borst, SE, Moningka, N, Krotova, K & Carter, CS 2013, 'Late-life Enalapril administration induces nitric oxide-dependent and independent metabolic adaptations in the rat skeletal muscle', Age, vol. 35, pagg. 1061-1075. https://doi.org/10.1007/s11357-012-9428-4

TY - JOUR

T1 - Late-life Enalapril administration induces nitric oxide-dependent and independent metabolic adaptations in the rat skeletal muscle

AU - Marzetti, Emanuele

AU - Calvani, Riccardo

AU - Dupree, Jameson

AU - Lees, Hazel A.

AU - Giovannini, Silvia

AU - Seo, Dong-Oh

AU - Buford, Thomas W.

AU - Sweet, Kindal

AU - Morgan, Drake

AU - Strehler, Kevin Y. E.

AU - Diz, Debra

AU - Borst, Stephen E.

AU - Moningka, Natasha

AU - Krotova, Karina

AU - Carter, Christy S.

PY - 2013

Y1 - 2013

N2 - Recently, we showed that administration of the angiotensin-converting enzyme inhibitor enalapril to aged rats attenuated muscle strength decline and mitigated apoptosis in the gastrocnemius muscle. The aimof the present study was to investigate possible mechanisms underlying the muscle-protective effects of enalapril. We also sought to discern the effects of enalapril mediated by nitric oxide (NO) from those independent mediated by mitigation of oxidative stress and proinflammatory signaling. © American Aging Association 2012.

AB - Recently, we showed that administration of the angiotensin-converting enzyme inhibitor enalapril to aged rats attenuated muscle strength decline and mitigated apoptosis in the gastrocnemius muscle. The aimof the present study was to investigate possible mechanisms underlying the muscle-protective effects of enalapril. We also sought to discern the effects of enalapril mediated by nitric oxide (NO) from those independent mediated by mitigation of oxidative stress and proinflammatory signaling. © American Aging Association 2012.

KW - ACE inhibitors

KW - Aging

KW - Glucose tolerance

KW - Inflammation

KW - L-NAME

KW - MTOR

KW - Mitochondria

KW - Nitric oxide synthase (NOS) isoforms

KW - ACE inhibitors

KW - Aging

KW - Glucose tolerance

KW - Inflammation

KW - L-NAME

KW - MTOR

KW - Mitochondria

KW - Nitric oxide synthase (NOS) isoforms

UR - http://hdl.handle.net/10807/220853

U2 - 10.1007/s11357-012-9428-4

DO - 10.1007/s11357-012-9428-4

M3 - Article

SN - 0161-9152

VL - 35

SP - 1061

EP - 1075

JO - Age

JF - Age

ER -

Late-life Enalapril administration induces nitric oxide-dependent and independent metabolic adaptations in the rat skeletal muscle

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Keywords

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