Latanoprost exposure in pregnancy.

Marco De Santis, A Lucchese, Brigida Carducci, Anna Franca Cavaliere, L De Santis, Am Merola, G Straface, Alessandro Caruso

Risultato della ricerca: Contributo in rivistaArticolo in rivista

46 Citazioni (Scopus)


PURPOSE: To observe pregnancies exposed to latanoprost, a prostaglandin analog administered in the treatment of glaucoma. Its prescription is limited in pregnancy, because reproduction studies in animals report a high incidence of abortion and human investigations are not adequate. As a consequence it is classified as category C drug according to the United States Food and Drug Administration's use-in-pregnancy ratings. DESIGN: Observational study. METHODS: We collected data, referred to our Teratology Information Service, relative to latanoprost exposure in pregnancy. We followed by phone interviews women treated with latanoprost during the first trimester, and we evaluated whether there had been any adverse effects on the fetus. RESULTS: Eleven cases of latanoprost exposure in pregnancy were referred to our Teratology Information Service. One case was lost to follow-up, and one case was complicated by miscarriage. Nine cases had a complete follow-up without congenital anomalies. CONCLUSIONS: Our series is too small to perform statistical significance; however, we found no evidence of adverse effects of latanoprost on pregnancy or neonatal outcomes.
Lingua originaleEnglish
pagine (da-a)305-306
Numero di pagine2
RivistaAmerican Journal of Ophthalmology
Stato di pubblicazionePubblicato - 2004


  • Congenital anomaly
  • Glaucoma
  • Latanoprost
  • Pregnancy


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