Laparoscopic liver resection of hepatocellular carcinoma located in unfavorable segments: a propensity score-matched analysis from the I Go MILS (Italian Group of Minimally Invasive Liver Surgery) Registry

Felice Giuliante, Anna Maria Antonucci, Antonio Giuliani, Carmelo Maria Antonio Parisi, Guido Torzilli, Giovanni Battista Levi Sandri, Giuseppe Maria Ettorre, Luca Aldrighetti, Umberto Cillo, Raffaele Dalla Valle, Alfredo Guglielmi, Vincenzo Mazzaferro, Alessandro Ferrero, Fabrizio Di Benedetto, Salvatore Gruttadauria, Luciano De Carlis, Giovanni Vennarecci, Adelmo Antonucci, Giulio Belli, Stefano BertiUgo Boggi, Pasquale Bonsignore, Alberto Brolese, Fulvio Calise, Graziano Ceccarelli, Michele Colledan, Andrea Coratti, Fabio Ferla, Antonio Floridi, Antonio Frena, Gian Luca Grazi, Enrico Gringeri, Guido Griseri, Maurizio Iaria, Elio Jovine, Paolo Magistri, Pietro Maida, Pietro Mezzatesta, Nadia Russolillo, Giuseppe Navarra, Amilcare Parisi, Antonio Daniele Pinna, Francesca Ratti, Giorgio Ettore Rossi, Andrea Ruzzenente, Roberto Santambrogio, Andrea Scotti, Giovanni Sgroi, Abdallah Slim, Leonardo Vincenti, Matteo Virdis, Fausto Zamboni

Risultato della ricerca: Contributo in rivistaArticolo in rivista

18 Citazioni (Scopus)

Abstract

Objective: Laparoscopic liver resection (LLR) for Hepatocellular Carcinoma (HCC) is one of the most important indications for the minimally invasive approach. Our study aims to analyze the experience of the Italian Group of Minimally Invasive Liver Surgery with laparoscopic surgical treatment of HCC, with a focus on tumor location and how it affects morbidity and mortality. Methods: 38 centers participated in this study; 372 cases of LLR for HCC were prospectively enrolled. Patients were divided into two groups according to the HCC nodule location. Group 1 favorable location and group 2 unfavorable location. Perioperative outcomes were compared between the two groups before and after a propensity score match (PS) 1:1. Results: Before PS in group 2 surgical time was longer; conversion rate was higher; postoperative transfusion and comprehensive complication index were also higher. PS was performed with a cohort of 298 patients (from 18 centers), with 66 and 232 patients with HCC in unfavorable and favorable locations, respectively. After PS matching, 62 patients from group 1 and group 2 each were compared. Operative and postoperative course were similar in patients with HCC in favorable and unfavorable LLR locations. Surgical margins were found to be identical before and after PS. Conclusions: These results show that LLR in patients with HCC can be safely performed in all segments because of the extensive experience of all surgeons from multiple centers in performing traditional open liver surgery as well as laparoscopic surgery.
Lingua originaleEnglish
pagine (da-a)1451-1458
Numero di pagine8
RivistaSurgical Endoscopy
Volume33
DOI
Stato di pubblicazionePubblicato - 2019

Keywords

  • Child B
  • Laparoscopy
  • IGoMILS
  • Laparoscopic HCC
  • Laparoscopic liver resection
  • Posterior segment
  • Aged
  • Blood Transfusion
  • Carcinoma, Hepatocellular
  • Female
  • Humans
  • Italy
  • Liver Neoplasms
  • Male
  • Margins of Excision
  • Matched-Pair Analysis
  • Middle Aged
  • Operative Time
  • Postoperative Care
  • Postoperative Complications
  • Prospective Studies
  • Registries
  • Hepatectomy
  • Hepatocellular carcinoma

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