TY - JOUR
T1 - Lacosamide inhibits calcitonin gene-related peptide production and release at trigeminal level in the rat
AU - Greco, Maria Cristina
AU - Capuano, Alessandro
AU - Navarra, Pierluigi
AU - Tringali, Giuseppe
PY - 2016
Y1 - 2016
N2 - Several classes of drugs are effective in prevention and treatment of migraine, although they may differ among each other in their mode of action and in indications. One such class is represented by antiepileptics. Lacosamide is an approved antiepileptic drug that also shows antinociceptive activity in animal models, including analgesic efficacy in central and trigeminal pain. Calcitonin gene-related peptide (CGRP) is considered the main neuro-mediator of trigeminal signalling, playing an essential role in headache, migraine in particular. Here, we investigated the effects of lacosamide on CGRP signalling in both in vitro and ex vivo/vitro models in the rat.
AB - Several classes of drugs are effective in prevention and treatment of migraine, although they may differ among each other in their mode of action and in indications. One such class is represented by antiepileptics. Lacosamide is an approved antiepileptic drug that also shows antinociceptive activity in animal models, including analgesic efficacy in central and trigeminal pain. Calcitonin gene-related peptide (CGRP) is considered the main neuro-mediator of trigeminal signalling, playing an essential role in headache, migraine in particular. Here, we investigated the effects of lacosamide on CGRP signalling in both in vitro and ex vivo/vitro models in the rat.
KW - CGRP
KW - LACOSAMIDE
KW - CGRP
KW - LACOSAMIDE
UR - https://publicatt.unicatt.it/handle/10807/70699
UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84969557093&origin=inward
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84969557093&origin=inward
U2 - 10.1002/ejp.820
DO - 10.1002/ejp.820
M3 - Article
SN - 1090-3801
SP - N/A-N/A
JO - European Journal of Pain
JF - European Journal of Pain
IS - N/A
ER -