Lacosamide inhibits calcitonin gene-related peptide production and release at trigeminal level in the rat

Pierluigi Navarra, Giuseppe Tringali, Maria Cristina Greco, Alessandro Capuano, A. Capuano

Risultato della ricerca: Contributo in rivistaArticolo in rivista

8 Citazioni (Scopus)

Abstract

Several classes of drugs are effective in prevention and treatment of migraine, although they may differ among each other in their mode of action and in indications. One such class is represented by antiepileptics. Lacosamide is an approved antiepileptic drug that also shows antinociceptive activity in animal models, including analgesic efficacy in central and trigeminal pain. Calcitonin gene-related peptide (CGRP) is considered the main neuro-mediator of trigeminal signalling, playing an essential role in headache, migraine in particular. Here, we investigated the effects of lacosamide on CGRP signalling in both in vitro and ex vivo/vitro models in the rat.
Lingua originaleEnglish
pagine (da-a)N/A-N/A
RivistaEuropean Journal of Pain
DOI
Stato di pubblicazionePubblicato - 2016

Keywords

  • CGRP
  • LACOSAMIDE

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