Lack of relationship between genotype and virulence in Candida species

Brunella Posteraro, Maurizio Sanguinetti, Judith Díaz-García, Maiken C. Arendrup, Rafael Cantón, Julio García-Rodríguez, Elia Gómez García De La Pedrosa, Gabriella Parisi, Javier Pemán, Daniel Archimedes Da Matta, Arnaldo L. Colombo, Patricia Muñoz, Carlos Sánchez-Carrillo, Jesús Guinea, Pilar Escribano

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

Background: The virulence of isolates among different Candida species causing candidemia may play a role in the prognosis of the patients. Furthermore, the potential relationship between genotype and virulence is still unclear and need to be further studied. Aims: We aim to assess the relationship between genotype and virulence in Candida species using a Galleria mellonella larvae infection model. Methods: One hundred and ninety-four isolates from 68 clusters (Candida albicans, 114/41; Candida parapsilosis, 74/24; Candida tropicalis, 6/3) were compared against the same number of each species singleton genotypes in terms of survival of G. mellonella larvae. Results: The median of survival and the IQR ranges of clusters and singleton were as follows: C. albicans (2 days, IQR 1.5–2 vs. 2 days, IQR 1–2.25), C. parapsilosis (2 days, IQR 1.5–2.6 vs. 2 days, IQR 2–3.3), and C. tropicalis (1 day, IQR 1–3.5 vs. 2 days, IQR 2–3.5; p < 0.05). High intra-cluster variability in terms of median of survival was found regardless the species. Conclusions: No relationship between genotype and virulence in Candida was observed with the G. mellonella model.
Titolo tradotto del contributo[Autom. eng. transl.] Lack of relationship between genotype and virulence in Candida species
Lingua originaleSpanish
pagine (da-a)N/A-N/A
RivistaRevista Iberoamericana de Micologia
DOI
Stato di pubblicazionePubblicato - 2020

Keywords

  • Candida albicans
  • Candida parapsilosis
  • Candida tropicalis
  • Galleria mellonella
  • Genotyping
  • Virulence

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