Lack of p53 decreases basal oxidative stress levels in the brain through upregulation of thioredoxin-1, biliverdin reductase-A, manganese superoxide dismutase, and nuclear factor kappa-B

Eugenio Barone; Giovanna Cenini; Rukhsana Sultana; Fabio Di Domenico; Ada Fiorini; Marzia Perluigi; Teresa Noel; Chi Wang; Cesare Mancuso; Daret K. St. Clair; D. Allan Butterfield

doi:10.1089/ars.2011.4124

Lack of p53 decreases basal oxidative stress levels in the brain through upregulation of thioredoxin-1, biliverdin reductase-A, manganese superoxide dismutase, and nuclear factor kappa-B

Eugenio Barone, Giovanna Cenini, Rukhsana Sultana, Fabio Di Domenico, Ada Fiorini, Marzia Perluigi, Teresa Noel, Chi Wang, Cesare Mancuso, Daret K. St. Clair, D. Allan Butterfield

Risultato della ricerca: Contributo in rivista › Articolo in rivista › peer review

18 Citazioni (Scopus)

Abstract

The basal oxidative and nitrosative stress levels measured in cytosol, mitochondria, and nuclei as well as in the whole homogenate obtained from the brain of wild type (wt) and p53 knockout [p53((-/-))] mice were evaluated. We hypothesized that the loss of p53 could trigger the activation of several protective mechanisms such as those involving thioredoxin-1 (Thio-1), the heme-oxygenase-1/biliverdin reductase-A (HO-1/BVR-A) system, manganese superoxide dismutase (MnSOD), the IkB kinase type β (IKKβ)/nuclear factor kappa-B (NF-kB), and the nuclear factor-erythroid 2 (NF-E2) related factor 2 (Nrf-2).

Lingua originale	English
pagine (da-a)	1407-1420
Numero di pagine	14
Rivista	ANTIOXIDANTS & REDOX SIGNALING
Volume	16
DOI	https://doi.org/10.1089/ars.2011.4124
Stato di pubblicazione	Pubblicato - 2012

Keywords

Biliverdin reductase-A
p53 KO mice

Accesso al documento

10.1089/ars.2011.4124

Altri file e collegamenti

Link a IRIS PubliCatt

Cita questo

Barone, E., Cenini, G., Sultana, R., Di Domenico, F., Fiorini, A., Perluigi, M., Noel, T., Wang, C., Mancuso, C., St. Clair, D. K., & Butterfield, D. A. (2012). Lack of p53 decreases basal oxidative stress levels in the brain through upregulation of thioredoxin-1, biliverdin reductase-A, manganese superoxide dismutase, and nuclear factor kappa-B. ANTIOXIDANTS & REDOX SIGNALING, 16, 1407-1420. https://doi.org/10.1089/ars.2011.4124

@article{1feb79cae2c049c9b3a90e5ad021d580,

title = "Lack of p53 decreases basal oxidative stress levels in the brain through upregulation of thioredoxin-1, biliverdin reductase-A, manganese superoxide dismutase, and nuclear factor kappa-B",

abstract = "The basal oxidative and nitrosative stress levels measured in cytosol, mitochondria, and nuclei as well as in the whole homogenate obtained from the brain of wild type (wt) and p53 knockout [p53((-/-))] mice were evaluated. We hypothesized that the loss of p53 could trigger the activation of several protective mechanisms such as those involving thioredoxin-1 (Thio-1), the heme-oxygenase-1/biliverdin reductase-A (HO-1/BVR-A) system, manganese superoxide dismutase (MnSOD), the IkB kinase type β (IKKβ)/nuclear factor kappa-B (NF-kB), and the nuclear factor-erythroid 2 (NF-E2) related factor 2 (Nrf-2).",

keywords = "Biliverdin reductase-A, p53 KO mice, Biliverdin reductase-A, p53 KO mice",

author = "Eugenio Barone and Giovanna Cenini and Rukhsana Sultana and {Di Domenico}, Fabio and Ada Fiorini and Marzia Perluigi and Teresa Noel and Chi Wang and Cesare Mancuso and {St. Clair}, {Daret K.} and Butterfield, {D. Allan}",

year = "2012",

doi = "10.1089/ars.2011.4124",

language = "English",

volume = "16",

pages = "1407--1420",

journal = "ANTIOXIDANTS & REDOX SIGNALING",

issn = "1523-0864",

publisher = "Mary Ann Liebert Incorporated:2 Madison Avenue:Larchmont, NY 10538:(914)834-3100, EMAIL: [email protected], [email protected], INTERNET: http://www.liebertpub.com, Fax: (914)834-3688",

}

Barone, E, Cenini, G, Sultana, R, Di Domenico, F, Fiorini, A, Perluigi, M, Noel, T, Wang, C, Mancuso, C, St. Clair, DK & Butterfield, DA 2012, 'Lack of p53 decreases basal oxidative stress levels in the brain through upregulation of thioredoxin-1, biliverdin reductase-A, manganese superoxide dismutase, and nuclear factor kappa-B', ANTIOXIDANTS & REDOX SIGNALING, vol. 16, pagg. 1407-1420. https://doi.org/10.1089/ars.2011.4124

Lack of p53 decreases basal oxidative stress levels in the brain through upregulation of thioredoxin-1, biliverdin reductase-A, manganese superoxide dismutase, and nuclear factor kappa-B. / Barone, Eugenio; Cenini, Giovanna; Sultana, Rukhsana et al.
In: ANTIOXIDANTS & REDOX SIGNALING, Vol. 16, 2012, pag. 1407-1420.

Risultato della ricerca: Contributo in rivista › Articolo in rivista › peer review

TY - JOUR

T1 - Lack of p53 decreases basal oxidative stress levels in the brain through upregulation of thioredoxin-1, biliverdin reductase-A, manganese superoxide dismutase, and nuclear factor kappa-B

AU - Barone, Eugenio

AU - Cenini, Giovanna

AU - Sultana, Rukhsana

AU - Di Domenico, Fabio

AU - Fiorini, Ada

AU - Perluigi, Marzia

AU - Noel, Teresa

AU - Wang, Chi

AU - Mancuso, Cesare

AU - St. Clair, Daret K.

AU - Butterfield, D. Allan

PY - 2012

Y1 - 2012

N2 - The basal oxidative and nitrosative stress levels measured in cytosol, mitochondria, and nuclei as well as in the whole homogenate obtained from the brain of wild type (wt) and p53 knockout [p53((-/-))] mice were evaluated. We hypothesized that the loss of p53 could trigger the activation of several protective mechanisms such as those involving thioredoxin-1 (Thio-1), the heme-oxygenase-1/biliverdin reductase-A (HO-1/BVR-A) system, manganese superoxide dismutase (MnSOD), the IkB kinase type β (IKKβ)/nuclear factor kappa-B (NF-kB), and the nuclear factor-erythroid 2 (NF-E2) related factor 2 (Nrf-2).

AB - The basal oxidative and nitrosative stress levels measured in cytosol, mitochondria, and nuclei as well as in the whole homogenate obtained from the brain of wild type (wt) and p53 knockout [p53((-/-))] mice were evaluated. We hypothesized that the loss of p53 could trigger the activation of several protective mechanisms such as those involving thioredoxin-1 (Thio-1), the heme-oxygenase-1/biliverdin reductase-A (HO-1/BVR-A) system, manganese superoxide dismutase (MnSOD), the IkB kinase type β (IKKβ)/nuclear factor kappa-B (NF-kB), and the nuclear factor-erythroid 2 (NF-E2) related factor 2 (Nrf-2).

KW - Biliverdin reductase-A

KW - p53 KO mice

KW - Biliverdin reductase-A

KW - p53 KO mice

UR - http://hdl.handle.net/10807/5906

U2 - 10.1089/ars.2011.4124

DO - 10.1089/ars.2011.4124

M3 - Article

SN - 1523-0864

VL - 16

SP - 1407

EP - 1420

JO - ANTIOXIDANTS & REDOX SIGNALING

JF - ANTIOXIDANTS & REDOX SIGNALING

ER -

Lack of p53 decreases basal oxidative stress levels in the brain through upregulation of thioredoxin-1, biliverdin reductase-A, manganese superoxide dismutase, and nuclear factor kappa-B

Abstract

Keywords

Accesso al documento

Altri file e collegamenti

Fingerprint

Cita questo