Lack of p53 decreases basal oxidative stress levels in the brain through upregulation of thioredoxin-1, biliverdin reductase-A, manganese superoxide dismutase, and nuclear factor kappa-B

Cesare Mancuso, Eugenio Barone, Giovanna Cenini, Rukhsana Sultana, Fabio Di Domenico, Ada Fiorini, Marzia Perluigi, Teresa Noel, Chi Wang, Daret K. St. Clair, D. Allan Butterfield

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

18 Citazioni (Scopus)

Abstract

The basal oxidative and nitrosative stress levels measured in cytosol, mitochondria, and nuclei as well as in the whole homogenate obtained from the brain of wild type (wt) and p53 knockout [p53((-/-))] mice were evaluated. We hypothesized that the loss of p53 could trigger the activation of several protective mechanisms such as those involving thioredoxin-1 (Thio-1), the heme-oxygenase-1/biliverdin reductase-A (HO-1/BVR-A) system, manganese superoxide dismutase (MnSOD), the IkB kinase type β (IKKβ)/nuclear factor kappa-B (NF-kB), and the nuclear factor-erythroid 2 (NF-E2) related factor 2 (Nrf-2).
Lingua originaleEnglish
pagine (da-a)1407-1420
Numero di pagine14
RivistaANTIOXIDANTS & REDOX SIGNALING
Volume16
DOI
Stato di pubblicazionePubblicato - 2012

Keywords

  • Biliverdin reductase-A
  • p53 KO mice

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