Lack of Effect of Nitrates on Exercise Stress Test Results in Patients with Microvascular Angina

Giulio Russo, Antonino Di Franco, Priscilla Lamendola, Pierpaolo Tarzia, Roberto Nerla, Alessandra Stazi, Angelo Villano, Alfonso Sestito, Gaetano Antonio Lanza, Filippo Crea

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

47 Citazioni (Scopus)


PURPOSE: To assess the effects of short-acting nitrates on exercise stress test (EST) results and the relation between EST results and coronary blood flow (CBF) response to nitrates in patients with microvascular angina (MVA). METHODS: We completed 2 symptom/sign limited ESTs on 2 separate days, in a random sequence and in pharmacological washout, in 29 MVA patients and in 24 patients with obstructive coronary artery disease (CAD): one EST was performed without any intervention (control EST, C-EST), and the other after sublingual isosorbide dinitrate, 5 mg (nitrate EST, N-EST). CBF response to nitroglycerin (25 μg) was assessed in the left anterior descending coronary artery by transthoracic Doppler-echocardiography. RESULTS: At C-EST. ST-segment depression ≥1 mm (STD) was induced in 26 (90 %) and 23 (96 %) MVA and CAD patients, respectively (p = 0.42), whereas at N-EST, STD was induced in 25 (86 %) and 14 (56 %) MVA and CAD patients, respectively (p = 0.01). Time and rate pressure product at 1 mm STD increased during N-EST, compared to C-EST, in CAD patients (475 ± 115 vs. 365 ± 146 s, p < 0.001; and 23511 ± 4352 vs. 20583 ± 6234 bpm[Symbol: see text]mmHg, respectively, p = 0.01), but not in MVA patients (308 ± 160 vs. 284 ± 136 s; p = 0.19; and 21290 ± 5438 vs. 20818 ± 4286 bpm[Symbol: see text]mmHg, respectively, p = 0.35). In MVA patients, a significant correlation was found between heart rate at STD during N-EST and CBF response to nitroglycerin (r = 0.40, p = 0.04). CONCLUSIONS: Short-acting nitrates improve EST results in CAD, but not in MVA patients. In MVA patients a lower nitrate-dependent coronary microvascular dilation may contribute to the lack of effects of nitrates on EST results.
Lingua originaleEnglish
pagine (da-a)N/A-N/A
RivistaCardiovascular Drugs and Therapy
Stato di pubblicazionePubblicato - 2013


  • Exercise stress test
  • NItrates
  • microvascular angina


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