l-Glutamate reduces the affinity of [3H]N-propylnorapomorphine binding sites in striatal membranes

Maria Martire, K Fuxe, Mf Celani, I Zini, M Zoli, Lf Agnati

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

25 Citazioni (Scopus)

Abstract

l-Glutamate but not methyl-D-aspartate (NMDA) or quisqualate ( Quis ) (10(-6 M) in vitro with or without preincubation increased significantly the KD value of the [3H]N-propylnorapomorphine ( [3H]NPA) binding sites by 21 and 36% respectively in striatal membranes of rat without influencing the striatal [3H]spiperone binding sites. The number of striatal [3H]NPA binding sites was not changed by l-glutamate (10(-6) and 10(-5) M) in vitro. There may thus exist interactions between striatal glutamate receptors -- not related to excitatory amino-acid receptors of the NMDA or the QUIS type -- and high affinity striatal DA receptors.
Lingua originaleEnglish
pagine (da-a)127-130
Numero di pagine4
RivistaEuropean Journal of Pharmacology
Volume100
Stato di pubblicazionePubblicato - 1984

Keywords

  • Animals
  • Antiparkinson Agents
  • Apomorphine
  • Aspartic Acid
  • Binding Sites
  • Cell Membrane
  • Corpus Striatum
  • Glutamates
  • Glutamic Acid
  • Male
  • N-Methylaspartate
  • Neuromuscular Depolarizing Agents
  • Oxadiazoles
  • Quisqualic Acid
  • Rats
  • Rats, Inbred Strains
  • Spiperone

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