Abstract
l-Glutamate but not methyl-D-aspartate (NMDA) or quisqualate ( Quis ) (10(-6 M) in vitro with or without preincubation increased significantly the KD value of the [3H]N-propylnorapomorphine ( [3H]NPA) binding sites by 21 and 36% respectively in striatal membranes of rat without influencing the striatal [3H]spiperone binding sites. The number of striatal [3H]NPA binding sites was not changed by l-glutamate (10(-6) and 10(-5) M) in vitro. There may thus exist interactions between striatal glutamate receptors -- not related to excitatory amino-acid receptors of the NMDA or the QUIS type -- and high affinity striatal DA receptors.
Lingua originale | English |
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pagine (da-a) | 127-130 |
Numero di pagine | 4 |
Rivista | European Journal of Pharmacology |
Volume | 100 |
Stato di pubblicazione | Pubblicato - 1984 |
Keywords
- Animals
- Antiparkinson Agents
- Apomorphine
- Aspartic Acid
- Binding Sites
- Cell Membrane
- Corpus Striatum
- Glutamates
- Glutamic Acid
- Male
- N-Methylaspartate
- Neuromuscular Depolarizing Agents
- Oxadiazoles
- Quisqualic Acid
- Rats
- Rats, Inbred Strains
- Spiperone