TY - JOUR
T1 - KIR B haplotype donors confer a reduced risk for relapse after haploidentical transplantation in children with ALL
AU - Oevermann, Lena
AU - Michaelis, Sebastian U.
AU - Mezger, Markus
AU - Lang, Peter
AU - Toporski, Jacek
AU - Bertaina, Alice
AU - Zecca, Marco
AU - Moretta, Lorenzo
AU - Locatelli, Franco
AU - Handgretinger, Rupert
PY - 2014
Y1 - 2014
N2 - We analyzed the influence of donor killer-cell immunoglobulin-like receptor (KIR) gene haplotypes on the risk for relapse and the probability of event-free survival (EFS) in children with acute lymphoblastic leukemia who received human leukocyte antigen-haploidentical transplantation of ex vivo T-cell-depleted peripheral blood stem cells. The KIR gene haplotype was evaluated in 85 donors, and the KIR B content score was determined in the 63 KIR haplotype B donors. Patients transplanted from a KIR haplotype B donor had a significantly better EFS than those transplanted from a KIR haplotype A donor (50.6% vs 29.5%, respectively; P = .033). Moreover, a high donor KIR B-content score was associated with a significantly reduced risk for relapse (Log-rank test for trend, P = .026). These data indicate that KIR genotyping should be included in the donor selection algorithm for haploidentical transplantation in children with acute lymphoblastic leukemia with the aim of choosing, whenever possible, a KIR haplotype B donor with a high KIR B-content score.
AB - We analyzed the influence of donor killer-cell immunoglobulin-like receptor (KIR) gene haplotypes on the risk for relapse and the probability of event-free survival (EFS) in children with acute lymphoblastic leukemia who received human leukocyte antigen-haploidentical transplantation of ex vivo T-cell-depleted peripheral blood stem cells. The KIR gene haplotype was evaluated in 85 donors, and the KIR B content score was determined in the 63 KIR haplotype B donors. Patients transplanted from a KIR haplotype B donor had a significantly better EFS than those transplanted from a KIR haplotype A donor (50.6% vs 29.5%, respectively; P = .033). Moreover, a high donor KIR B-content score was associated with a significantly reduced risk for relapse (Log-rank test for trend, P = .026). These data indicate that KIR genotyping should be included in the donor selection algorithm for haploidentical transplantation in children with acute lymphoblastic leukemia with the aim of choosing, whenever possible, a KIR haplotype B donor with a high KIR B-content score.
KW - N/A
KW - N/A
UR - http://hdl.handle.net/10807/241794
U2 - 10.1182/blood-2014-03-565069
DO - 10.1182/blood-2014-03-565069
M3 - Article
SN - 1528-0020
VL - 124
SP - 2744
EP - 2747
JO - Blood
JF - Blood
ER -