Kinetics of hepatitis C virus RNA decay, quasispecies evolution and risk of virological failure during telaprevir-based triple therapy in clinical practice

Pierluigi Navarra, Valeria Cento, Monica Tontodonati, Velia Chiara Di Maio, Maria Concetta Bellocchi, Fabrizio Valenti, Alessandra Manunta, Daniele Armenia, Luca Carioti, Francesco Paolo Antonucci, Ada Bertoli, Francesca Trave, Pierluigi Cacciatore, Mario Angelico, Avidan U. Neumann, Jacopo Vecchiet, Giustino Parruti, Sergio Babudieri, Carlo Federico Perno, Francesca Ceccherini-Silberstein

Risultato della ricerca: Contributo in rivistaArticolo in rivista

4 Citazioni (Scopus)

Abstract

The used first generation protease inhibitors may be hampered by virological failure in partially interferon-sensitive patients.
Lingua originaleEnglish
pagine (da-a)233-241
Numero di pagine9
RivistaDIGESTIVE AND LIVER DISEASE
Volume47
DOI
Stato di pubblicazionePubblicato - 2015

Keywords

  • Aged
  • Antiviral Agents
  • Drug Resistance, Viral
  • Drug Therapy, Combination
  • Drug-resistance
  • Female
  • Genotype
  • Hepacivirus
  • Hepatitis C, Chronic
  • Humans
  • Interferon-alpha
  • Linear Models
  • Male
  • Mathematical modelling
  • Middle Aged
  • Mutation
  • Oligopeptides
  • Protease Inhibitors
  • Protease inhibitors
  • RNA Stability
  • RNA, Viral
  • Ribavirin
  • Treatment Outcome
  • Viral Load
  • Viral kinetic
  • Virus Replication

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