Juvenile myoclonic epilepsy and Brugada type 1 ECG pattern associated with (a novel) plakophillin 2 mutation

Antonio Oliva, Lorenzo Gigli, Giovanni Bertero, Monica Coll Vidal, Anna Iglesias, Oscar Campuzano, Pasquale Striano, Ramon Brugada

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

Sudden unexpected death is a catastrophic complicationof human epilepsy with an incidence of 6.3–9.3 per 1000person years in epilepsy patients entering surgery programs[1]. However, mechanisms and methods to prevent it arestill largely unknow n. A leading hypothesis suggests adysfunction of excitability that could underlie both epi-lepsy and cardiac arrhythmias, leading to death [1, 2]. Inrecent years, there has been increased interest in a possibleassociation between epilepsy channelopathies and cardiacarrhythmias. We report a patient with juvenile myoclonic epilepsy(JME or Janz’s syndrome) and a Brugada diagnostic ECGpattern revealed after a convulsive seizure. Genetic anal-ysis revealed a novel mutation in the PKP2 gene, encodingplakophilin 2, a myocardial desmosomal protein, which hasbeen associated with cardiac arrhythmias [5]. This obser-vation provides further evidence for a possible linkbetween idiopathic epilepsy and cardiac arrhythmias andthe related possible implication for Sudden UnexpectedDeath in EPilepsy (SUDEP) pathophysiology.
Lingua originaleEnglish
pagine (da-a)792-795
Numero di pagine4
RivistaJournal of Neurology
Volume264
DOI
Stato di pubblicazionePubblicato - 2017

Keywords

  • Neurology
  • Neurology (clinical)

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