Jejunal proteins secreted by db/db mice or insulin-resistant humans impair the insulin signaling and determine insulin resistance

S Salinari; C Debard; A Bertuzzi; C Durand; P Zimmet; H Vidal; Geltrude Mingrone

doi:10.1371/journal.pone.0056258

Jejunal proteins secreted by db/db mice or insulin-resistant humans impair the insulin signaling and determine insulin resistance

S Salinari, C Debard, A Bertuzzi, C Durand, P Zimmet, H Vidal, Geltrude Mingrone^*

^*Autore corrispondente per questo lavoro

Risultato della ricerca: Contributo in rivista › Articolo

41 Citazioni (Scopus)

Abstract

Two recent studies demonstrated that bariatric surgery induced remission of type 2 diabetes very soon after surgery and far too early to be attributed to weight loss. In this study, we sought to explore the mechanism/s of this phenomenon by testing the effects of proteins from the duodenum-jejunum conditioned-medium (CM) of db/db or Swiss mice on glucose uptake in vivo in Swiss mice and in vitro in both Swiss mice soleus and L6 cells. We studied the effect of sera and CM proteins from insulin resistant (IR) and insulin-sensitive subjects on insulin signaling in human myoblasts.

Lingua originale	Inglese
pagine (da-a)	e56258-e56258
Rivista	PLoS One
Volume	8
Numero di pubblicazione	2
DOI	https://doi.org/10.1371/journal.pone.0056258
Stato di pubblicazione	Pubblicato - 2013

All Science Journal Classification (ASJC) codes

Multidisciplinare

Keywords

70-kDa
Adult
Animals
Cell Differentiation
Conditioned
Culture Media
Deoxyglucose
Diabetes Mellitus
Experimental
Glycogen Synthase Kinase 3
Humans
Inbred C57BL
Insulin
Insulin Resistance
Jejunum
Mice
Muscle Fibers
Phosphorylation
Phosphoserine
Proteins
Proto-Oncogene Proteins c-akt
Ribosomal Protein S6 Kinases
Signal Transduction
Skeletal

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10.1371/journal.pone.0056258

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abstract = "Two recent studies demonstrated that bariatric surgery induced remission of type 2 diabetes very soon after surgery and far too early to be attributed to weight loss. In this study, we sought to explore the mechanism/s of this phenomenon by testing the effects of proteins from the duodenum-jejunum conditioned-medium (CM) of db/db or Swiss mice on glucose uptake in vivo in Swiss mice and in vitro in both Swiss mice soleus and L6 cells. We studied the effect of sera and CM proteins from insulin resistant (IR) and insulin-sensitive subjects on insulin signaling in human myoblasts.",

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AU - Zimmet, P

AU - Vidal, H

AU - Mingrone, Geltrude

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Jejunal proteins secreted by db/db mice or insulin-resistant humans impair the insulin signaling and determine insulin resistance

Abstract

All Science Journal Classification (ASJC) codes

Keywords

OSS delle Nazioni Unite

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