Jejunal proteins secreted by db/db mice or insulin-resistant humans impair the insulin signaling and determine insulin resistance

S Salinari, C Debard, A Bertuzzi, C Durand, P Zimmet, H Vidal, Geltrude Mingrone*

*Autore corrispondente per questo lavoro

Risultato della ricerca: Contributo in rivistaArticolo

41 Citazioni (Scopus)

Abstract

Two recent studies demonstrated that bariatric surgery induced remission of type 2 diabetes very soon after surgery and far too early to be attributed to weight loss. In this study, we sought to explore the mechanism/s of this phenomenon by testing the effects of proteins from the duodenum-jejunum conditioned-medium (CM) of db/db or Swiss mice on glucose uptake in vivo in Swiss mice and in vitro in both Swiss mice soleus and L6 cells. We studied the effect of sera and CM proteins from insulin resistant (IR) and insulin-sensitive subjects on insulin signaling in human myoblasts.
Lingua originaleInglese
pagine (da-a)e56258-e56258
RivistaPLoS One
Volume8
Numero di pubblicazione2
DOI
Stato di pubblicazionePubblicato - 2013

All Science Journal Classification (ASJC) codes

  • Multidisciplinare

Keywords

  • 70-kDa
  • Adult
  • Animals
  • Cell Differentiation
  • Conditioned
  • Culture Media
  • Deoxyglucose
  • Diabetes Mellitus
  • Experimental
  • Glycogen Synthase Kinase 3
  • Humans
  • Inbred C57BL
  • Insulin
  • Insulin Resistance
  • Jejunum
  • Mice
  • Muscle Fibers
  • Phosphorylation
  • Phosphoserine
  • Proteins
  • Proto-Oncogene Proteins c-akt
  • Ribosomal Protein S6 Kinases
  • Signal Transduction
  • Skeletal

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