Jejunal proteins secreted by db/db mice or insulin-resistant humans impair the insulin signaling and determine insulin resistance

Geltrude Mingrone, Serenella Salinari, Cyrille Debard, Alessandro Bertuzzi, Christine Durand, Paul Zimmet, Hubert Vidal

Risultato della ricerca: Contributo in rivistaArticolo in rivista

41 Citazioni (Scopus)

Abstract

Two recent studies demonstrated that bariatric surgery induced remission of type 2 diabetes very soon after surgery and far too early to be attributed to weight loss. In this study, we sought to explore the mechanism/s of this phenomenon by testing the effects of proteins from the duodenum-jejunum conditioned-medium (CM) of db/db or Swiss mice on glucose uptake in vivo in Swiss mice and in vitro in both Swiss mice soleus and L6 cells. We studied the effect of sera and CM proteins from insulin resistant (IR) and insulin-sensitive subjects on insulin signaling in human myoblasts.
Lingua originaleEnglish
pagine (da-a)e56258-e56258
RivistaPLoS One
Volume8
DOI
Stato di pubblicazionePubblicato - 2013

Keywords

  • Adult
  • Animals
  • Cell Differentiation
  • Culture Media, Conditioned
  • Deoxyglucose
  • Diabetes Mellitus, Experimental
  • Glycogen Synthase Kinase 3
  • Humans
  • Insulin
  • Insulin Resistance
  • Jejunum
  • Mice
  • Mice, Inbred C57BL
  • Muscle Fibers, Skeletal
  • Phosphorylation
  • Phosphoserine
  • Proteins
  • Proto-Oncogene Proteins c-akt
  • Ribosomal Protein S6 Kinases, 70-kDa
  • Signal Transduction

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