TY - JOUR
T1 - Ivabradine in acute coronary syndromes: Protection beyond heart rate lowering
AU - Niccoli, Giampaolo
AU - Borovac, Josip Anđelo
AU - Vetrugno, Vincenzo
AU - Camici, Paolo G
AU - Crea, Filippo
PY - 2017
Y1 - 2017
N2 - Ivabradine is a heart rate reducing agent that exhibits anti-ischemic effects through the inhibition of funny electrical current in the sinus node resulting in heart rate reduction, thus enabling longer diastolic perfusion time, and reduced myocardial oxygen consumption without detrimental changes in arterial blood pressure, coronary vasomotion, and ventricular contractility. The current guideline-based clinical use of Ivabradine is reserved for patients with stable angina pectoris who cannot tolerate or whose symptoms are inadequately controlled with beta blockers. In patients with chronic heart failure and reduced ejection fraction, Ivabradine has demonstrated beneficial effects in improving clinical outcomes when added to conventional therapy. However, the role of Ivabradine in acute coronary syndromes has not been established. Based on the results from some relevant preclinical studies and a limited amount of clinical data that were reported recently, the role of Ivabradine in acute ischemic events warrants further investigation. The aim of this review is to provide an overview of the available literature on the potential role of Ivabradine in the clinical context of acute coronary syndromes.
AB - Ivabradine is a heart rate reducing agent that exhibits anti-ischemic effects through the inhibition of funny electrical current in the sinus node resulting in heart rate reduction, thus enabling longer diastolic perfusion time, and reduced myocardial oxygen consumption without detrimental changes in arterial blood pressure, coronary vasomotion, and ventricular contractility. The current guideline-based clinical use of Ivabradine is reserved for patients with stable angina pectoris who cannot tolerate or whose symptoms are inadequately controlled with beta blockers. In patients with chronic heart failure and reduced ejection fraction, Ivabradine has demonstrated beneficial effects in improving clinical outcomes when added to conventional therapy. However, the role of Ivabradine in acute coronary syndromes has not been established. Based on the results from some relevant preclinical studies and a limited amount of clinical data that were reported recently, the role of Ivabradine in acute ischemic events warrants further investigation. The aim of this review is to provide an overview of the available literature on the potential role of Ivabradine in the clinical context of acute coronary syndromes.
KW - Acute coronary syndrome
KW - Cardiology and Cardiovascular Medicine
KW - Ivabradine
KW - Medicine (all)
KW - Myocardial infarction
KW - Myocardial ischemia
KW - Myocardial reperfusion injury
KW - Acute coronary syndrome
KW - Cardiology and Cardiovascular Medicine
KW - Ivabradine
KW - Medicine (all)
KW - Myocardial infarction
KW - Myocardial ischemia
KW - Myocardial reperfusion injury
UR - http://hdl.handle.net/10807/98900
UR - http://www.elsevier.com/locate/ijcard
U2 - 10.1016/j.ijcard.2017.02.046
DO - 10.1016/j.ijcard.2017.02.046
M3 - Article
SN - 0167-5273
SP - 107
EP - 112
JO - International Journal of Cardiology
JF - International Journal of Cardiology
ER -