Italian consensus statement on management of HIV-infected individualswith advanced disease naive to antiretroviral therapy

Roberto Cauda, Adriana Ammassari, Andrea De Luca, Andrea Antinori, Carlo Torti, Patrizia Marconi, Massimo Andreoni, Gioacchino Angarano, Stefano Bonora, Antonella Castagna, Mario Clerici, Antonella D'Arminio Monforte, Giovanni Di Perri, M Galli, E Girardi, Andrea Gori, Adriano Lazzarin, S Lo Caputo, Francesco Mazzotta, F MontellaCristina Mussini, Cf Perno, M Puoti, Giuliano Rizzardini, Stefano Rusconi, Vincenzo Vullo, Giampiero Carosi

Risultato della ricerca: Contributo in rivistaArticolo in rivista

9 Citazioni (Scopus)

Abstract

BACKGROUND: Individuals with advanced HIV infection naïve to antiretroviral therapy represent a special population of patients frequently encountered in clinical practice. They are at high risk of disease progression and death, and their viroimmunologic response following the initiation of highly active antiretroviral therapy may be more incomplete or slower than that of other patients. Infection management in such patients can also be complicated by underlying conditions, comorbidities, and the need for concomitant medications. AIM: To provide practical guidelines to those clinicians providing care to HIV-infected patients in terms of diagnostic assessment, monitoring, and treatment. CONCLUSIONS: The principals of antiretroviral treatment in asymptomatic naïve patients with advanced HIV infection are the same as those applicable to the general population with asymptomatic HIV infection. Naïve patients with advanced HIV infection and a history of AIDS-defining illnesses urgently need antiretroviral treatment, with the choice of antiretroviral regimen and timetable based on such factors as concomitant treatment and prophylaxis, drug interactions, and potential concomitant drug toxicity. Finally, an adequate counseling program - both before and after HIV-testing - that includes aspects other than treatment adherence monitoring is a crucial step in disease management.
Lingua originaleEnglish
pagine (da-a)270-282
Numero di pagine13
RivistaInfection
Volume37
Stato di pubblicazionePubblicato - 2009

Keywords

  • antiretroviral therapy
  • consensus
  • management
  • naive

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