TY - JOUR
T1 - Isolated light chain deposition disease neuropathy in a patient with multiple myeloma
AU - Romano, Angela
AU - Riso, Vittorio
AU - Bisogni, Giulia
AU - Di Paolantonio, Andrea
AU - Rossi, Elena
AU - Sabatelli, Mario
AU - Servidei, Serenella
AU - Luigetti, Marco
PY - 2020
Y1 - 2020
N2 - In our patient, clinical history, neurological examination
and NCS revealed a progressive axonal sensory-motor polyneuropathy.
Although the presence of a polyneuropathy in
patients with MM is quite common, the rapid progression
of her clinical condition suggested a direct association with
the underlying hematologic disease [3]. Ruled out other possible
causes of neuropathy, we performed nerve biopsy,
detecting abundant light chain deposition and thus confirming
an aggressive hematologic disease, although other organs
(including kidney and heart) were not involved. Based on
these considerations, our patient was treated with chemotherapy,
resulting in clinical stabilization.
This report confirms that LCDD, although rare, could be
one of the several mechanisms of nerve damage in hematologic
diseases and could occur even without signs of other
organ involvement. Since its recognition has important
therapeutic implications, nerve biopsy is an irreplaceable
diagnostic tool in patients with progressive neuropathy during
hematologic disease.
AB - In our patient, clinical history, neurological examination
and NCS revealed a progressive axonal sensory-motor polyneuropathy.
Although the presence of a polyneuropathy in
patients with MM is quite common, the rapid progression
of her clinical condition suggested a direct association with
the underlying hematologic disease [3]. Ruled out other possible
causes of neuropathy, we performed nerve biopsy,
detecting abundant light chain deposition and thus confirming
an aggressive hematologic disease, although other organs
(including kidney and heart) were not involved. Based on
these considerations, our patient was treated with chemotherapy,
resulting in clinical stabilization.
This report confirms that LCDD, although rare, could be
one of the several mechanisms of nerve damage in hematologic
diseases and could occur even without signs of other
organ involvement. Since its recognition has important
therapeutic implications, nerve biopsy is an irreplaceable
diagnostic tool in patients with progressive neuropathy during
hematologic disease.
KW - neuropathy, light chain, myeloma
KW - neuropathy, light chain, myeloma
UR - http://hdl.handle.net/10807/148762
U2 - 10.1080/13506129.2019.1669554
DO - 10.1080/13506129.2019.1669554
M3 - Article
SN - 1350-6129
VL - 27
SP - 67
EP - 68
JO - AMYLOID
JF - AMYLOID
ER -