Is there a role for IGF1R and c-MET pathways in resistance to cetuximab in metastatic colorectal cancer?

Alessandro Inno; Mariantonietta Di Salvatore; Tonia Cenci; Maurizio Martini; Armando Orlandi; Antonia Strippoli; Anna Maria Ferrara; Cinzia Bagala'; Alessandra Cassano; Luigi Maria Larocca; Carlo Antonio Barone

doi:10.1016/j.clcc.2011.03.028

Is there a role for IGF1R and c-MET pathways in resistance to cetuximab in metastatic colorectal cancer?

Alessandro Inno
, Mariantonietta Di Salvatore
, Tonia Cenci
, Maurizio Martini
, Armando Orlandi
, Antonia Strippoli
, Anna Maria Ferrara
, Cinzia Bagala'
, Alessandra Cassano
, Luigi Maria Larocca
, Carlo Antonio Barone

Risultato della ricerca: Contributo in rivista › Articolo

65 Citazioni (Scopus)

Abstract

The KRAS mutation is not responsible for all cases of resistance to anti-epidermal growth factor receptors (EGFRs) in metastatic colorectal cancer (mCRC), and new predictive and prognostic factors are actively being sought.

Lingua originale	Inglese
pagine (da-a)	325-332
Numero di pagine	8
Rivista	Clinical Colorectal Cancer
Volume	10
Numero di pubblicazione	4
DOI	https://doi.org/10.1016/j.clcc.2011.03.028
Stato di pubblicazione	Pubblicato - 2011

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Keywords

80 and over
Adult
Aged
Antibodies
Antineoplastic Agents
Biological
Colorectal Neoplasms
DNA
Drug Resistance
Epidermal Growth Factor
Female
Gene Expression Regulation
Humans
IGF Type 1
Immunoenzyme Techniques
Male
Middle Aged
Monoclonal
Mutation
Neoplasm
Neoplasm Metastasis
Neoplastic
PTEN Phosphohydrolase
Polymerase Chain Reaction
Prognosis
Proto-Oncogene Proteins
Proto-Oncogene Proteins B-raf
Proto-Oncogene Proteins c-met
Receptor
Retrospective Studies
Survival Rate
Tumor Markers
ras Proteins

Accesso al documento

10.1016/j.clcc.2011.03.028

Altri file e collegamenti

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Cita questo

@article{333c6ed724a64767a9fd1d6049518062,

title = "Is there a role for IGF1R and c-MET pathways in resistance to cetuximab in metastatic colorectal cancer?",

abstract = "The KRAS mutation is not responsible for all cases of resistance to anti-epidermal growth factor receptors (EGFRs) in metastatic colorectal cancer (mCRC), and new predictive and prognostic factors are actively being sought.",

keywords = "80 and over, Adult, Aged, Antibodies, Antineoplastic Agents, Biological, Colorectal Neoplasms, DNA, Drug Resistance, Epidermal Growth Factor, Female, Gene Expression Regulation, Humans, IGF Type 1, Immunoenzyme Techniques, Male, Middle Aged, Monoclonal, Mutation, Neoplasm, Neoplasm Metastasis, Neoplastic, PTEN Phosphohydrolase, Polymerase Chain Reaction, Prognosis, Proto-Oncogene Proteins, Proto-Oncogene Proteins B-raf, Proto-Oncogene Proteins c-met, Receptor, Retrospective Studies, Survival Rate, Tumor Markers, ras Proteins, 80 and over, Adult, Aged, Antibodies, Antineoplastic Agents, Biological, Colorectal Neoplasms, DNA, Drug Resistance, Epidermal Growth Factor, Female, Gene Expression Regulation, Humans, IGF Type 1, Immunoenzyme Techniques, Male, Middle Aged, Monoclonal, Mutation, Neoplasm, Neoplasm Metastasis, Neoplastic, PTEN Phosphohydrolase, Polymerase Chain Reaction, Prognosis, Proto-Oncogene Proteins, Proto-Oncogene Proteins B-raf, Proto-Oncogene Proteins c-met, Receptor, Retrospective Studies, Survival Rate, Tumor Markers, ras Proteins",

author = "Alessandro Inno and \{Di Salvatore\}, Mariantonietta and Tonia Cenci and Maurizio Martini and Armando Orlandi and Antonia Strippoli and Ferrara, \{Anna Maria\} and Cinzia Bagala' and Alessandra Cassano and Larocca, \{Luigi Maria\} and Barone, \{Carlo Antonio\}",

year = "2011",

doi = "10.1016/j.clcc.2011.03.028",

language = "English",

volume = "10",

pages = "325--332",

journal = "Clinical Colorectal Cancer",

issn = "1533-0028",